浅沼浩之

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2024

原著論文

1. "Photosensitization of TiO2 Electrodes Immobilized with Chiral Plasmonic Au Nanocolloids by Circularly Polarized Light Irradiation"
   Kameyama, T.; Isogawa, S.; Akiyoshi, K.; Kashida, H.; Asanuma, H.; Torimoto, T.
   J. Chem. Phys., 2024, accepted, . DOI:
   
2. "Site-selective photo-crosslinking of stilbene pairs in a DNA duplex mediated by ruthenium photocatalyst"
   Kashida, H.; Azuma, H.; Sotome, H.; Miyasaka, H.; Asanuma, H.
   Angew. Chem. Int. Ed., 2024, 63, e202319516. DOI: https://doi.org/10.1002/anie.202319516
   Selected as a "Inside back cover"
   Selected as a "Hot paper"
   
3. "DNA reaction system that acquires classical conditioning"
   Nakakuki, T.; Toyonari, M.; Aso, K.; Murayama, K.; Asanuma, H.; de Greef, T.
   ACS Synth. Biol., 2024, accepted, . DOI:
   
4. "Unexpectedly stable homopurine parallel triplex of SNA:RNA*SNA and L-aTNA:RNA*L-aTNA"
   Kamiya, Y.; Lao, S.; Ariyoshi, J.; Sato, F.; Asanuma, H.
   Chem. Commun., 2024, 60, 1257-1260. DOI: doi.org/10.1039/D3CC05555H
   Selected as a "Front Cover"
   

2023

原著論文

1. "Illuminating miRNA inhibition: Visualizing the interaction between anti-miRNA oligonucleotide and target miRNA using FRET"
   Zhu, H.; Kamiya, Y.; Asanuma, H.
   ACS Chem. Biol., 2023, 18, 2281-2289. DOI: doi.org/10.1021/acschembio.3c00353
   Selected as a "Front Cover"
2. "Rapid Chemical Ligation of DNA and Acyclic Threoninol Nucleic Acid (aTNA) for Effective Nonenzymatic Primer Extension "
   Okita, H.; Kondo, S.; Murayama, K.; Asanuma, H.
   J. Am. Chem. Soc., 2023, 145, 17872-17880. DOI: 10.1021/jacs.3c04979
   Selected as a "Supplementary Cover"
3. "Orientational control of circularly polarized luminescence from pyrene clusters using a DNA scaffold"
   Kashida, H.; Ito, Y.; Kakuta, T.; Ogoshi, T.; Asanuma, H.
   Chem. Eur. J., 2023, e202300182. DOI: doi.org/10.1002/chem.202300182
   Selected as a "Front Cover"
4. "Syntheses of base-labile pseudo-complementary SNA and L-aTNA phosphoramidite monomers"
   Sato, F.; Kamiya, Y.; Asanuma, H.
   J. Org. Chem., 2023, 88, 796-804. DOI: 10.1021/acs.joc.2c01911
   Selected as a "Supplementary Cover"

解説論文

1. "Highly Functional Acyclic Xeno Nucleic Acids"
   Murayama, K.; Okita, H.; Asanuma, H.
   Bull. Chem. Soc. Jpn., 2023, 96, 1179-1187. DOI: doi.org/10.1246/bcsj.20230188
   
2. "Functionalization of Acyclic Xenonucleic Acid with Modified Nucleobases"
   Murayama, K.; Yamano, Y.; Asanuma, H.
   Polym. J., 2023, 55, 743-752. DOI: doi.org/10.1038/s41428-023-00776-7
   

著書

2022

原著論文

1. "DNA Concentration Regulator That can be Driven for a Long Time"
   Nakakuki, T.; Murayama, K.; Asanuma, H.
   New Gener. Comput., 2022, 40, 681-702. DOI: https://doi.org/10.1007/s00354-022-00173-3
   
2. "Kinesin motors driven microtubule swarming triggered by UV light"
   Ishii, S.; Akter, M.; Murayama, K.; Kabir, A. M. R.; Asanuma, H.; Sada, K.; Kakugo, A.
   Polym. J., 2022, 54, 1501-1507. DOI: https://doi.org/10.1038/s41428-022-00693-1
   
3. "Cooperative cargo transportation by a swarm of molecular machines"
   Akter, M.; Keya, J. J.; Kayano, K.; Kabir, A. M. R.; Inoue, D.; Hess, H.; Sada, K.; Kuzuya, A.; Asanuma, H.; Kakugo, A.
   Sci. Robot., 2022, 7, eabm0677. DOI: 10.1126/scirobotics.abm0677
   
4. "Methyl group configuration on acyclic threoninol nucleic acids (aTNAs) impacts supramolecular properties"
   Murayama, K.; Kashida, H.; Asanuma, H.
   Org. Biomol. Chem., 2022, 20, 4115-4122. DOI: 10.1039/d2ob00266c
   Selected as a "Front Cover"
5. "Orthogonal amplification circuits composed of acyclic nucleic acids enable RNA detection"
   Chen, Y.; Nagao, R.; Murayama, K.; Asanuma, H.
   J. Am. Chem. Soc., 2022, 144, 5887-5892. DOI: 10.1021/jacs.1c12659
   Selected as a "Supplementary Cover"
6. "Renewable DNA proportional-integral controller with photoresponsive molecules"
   Tamba, M.; Murayama, K.; Asanuma, H.; Nakakuki, T.
   Micromachines, 2022, 13, 193. doi.org/10.3390/mi13020193
   
7. "Color-Changing Fluorescent Barcode Based on Strand Displacement Reaction Enables Simple Multiplexed Labeling"
   Makino, K.; Susaki, E.; Endo, M.; Asanuma, H.; Kashida, H.
   J. Am. Chem. Soc., 2022, 144, 1572-1579. DOI: 10.1021/jacs.1c09844
8. "Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection"
   Chen, Y.; Murayama, K.; Asanuma, H.
   Chem. Lett., 2022, 51, 330-333. DOI:10.1246/cl.210813
   
9. "Unexpected Dissociation of Photoresponsive UV-ON DNA Carrying p-tert-Butyl Azobenzene under UV Light Irradiation"
   Ishii, S.; Murayama, K.; Sada, K.; Asanuma, H.; Kakugo, A.
   Chem. Lett., 2022, 51, 292-295. DOI:10.1246/cl.210788
   

解説論文

1. "DNA二重鎖を利用したFRET配向依存性の検討"
   樫田　啓, 浅沼浩之
   光化学, 2022, 53 (3), 148-153.
   
2. "RNA以前の世界を妄想する"
   浅沼浩之, 村山恵司
   化学と工業, 2022, 75 (8), 552-554.
   
3. "Xeno nucleic acids (XNAs) having non-ribose scaffolds with unique supramolecular properties"
   Asanuma, H.; Kamiya, Y.; Kashida, H.; Murayama, K.
   Chem. Commun., 2022, 28, 3993. DOI: 10.1039/d1cc05868a
   Selected as a "Front cover"

著書

1. "6.5 Orthogonality of Nucleic Acids"
   Keiji Murayama, Hiroyuki Asanuma
   "Molecular Robotics An Introduction", Satoshi Murata Ed., Springer, p.230-238. (2022)
2. "2-26　DNAポリマー"
   村山恵司、浅沼浩之
   "高分子材料の事典", 高分子学会編, 朝倉書店 (2022)

2021

原著論文

1. "Pyrene modified serinol nucleic acid nanostructure converts chirality of threoninol nucleic acids into circularly polarized luminescence signals"
   Kashida, H.; Nishikawa, K.; Ito Y.; Murayama, K.; Hayashi, I.; Kakuta, T.; Ogoshi, T.; Asanuma, H.
   Chem. Eur. J., 2021, 27, 14582-14585. DOI: 10.1002/chem.202102333
   Selected as a "Cover Feature"
2. "Perylene-Cy3 FRET System to Analyze Photoactive DNA Structures"
   Kawai, H.; Doi, T.; Ito Y.; Kameyama T.; Torimoto T.; Kashida, H.; Asanuma, H.
   Chem. Eur. J., 2021, 27, 12845-12850. DOI: 10.1002/chem.202101738
   
3. "Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA"
   Takahashi, H.; Yasui, T.; Kashida, H.; Makino, K.; Shinjo, K.; Liu, Q.; Shimada, T.; Rahong, S.; Kaji, N.; Asanuma, H.; Baba, Y.
   Nanotechnology, 2021, 32, 255301. DOI: 10.1088/1361-6528/abef2c
   
4. "Preparation of artificial hexaplex composed of non-natural nucleic acid"
   Makino, K.; Hattori, Y.; Kashida, H.; Asanuma, H.
   Current Protocols, 2021, 1, e106. DOI: 10.1002/cpz1.106
   
5. "Development of pre-miRNAs modification with FRET dye pair for intracellular visualization of processing intermediates generated in cells"
   Kamiya, Y.; Kamimoto, H.; Zhu, H. ; Asanuma, H.
   Sensors, 2021, 21, 1785. doi.org/10.3390/s21051785
   
6. "Light-regulated liquid-liquid phase separation for spatiotemporal protein recruitment and cell aggregation"
   Ikeuchi, N.; Komachi, T.; Murayama, K.; Asanuma, H.; Maruyama, A.; Shimada, N.
   ACS Appl. Mater. Interfaces, 2021, 13, 5652-5659. DOI: 10.1021/acsami.0c22314
   
7. "Nonenzymatic polymerase-like template-directed synthesis of acyclic L-threoninol nucleic acid"
   Murayama, K.; Okita, H.; Kuriki, T.; Asanuma, H.
   Nat. Commun., 2021, 12, 804. DOI: 10.1038s41467-021-21128-0
   Selected as a featured article
8. "Helical amplification system composed of artificial nucleic acids"
   Kashida, H.; Nishikawa, K.; Shi, W.; Miyagawa, T.; Yamashita, H.; Abe, M.; Asanuma, H.
   Chem. Sci., 2021, 12,1656-1660. DOI: 10.1039/d0sc05245k
   Selected as "Outside Backcover"
9. "Dual crosslinking photo-switches for orthogonal photo-control of hybridization between serinol nucleic acid and RNA"
   Yamano, Y.; Murayama, K.; Asanuma, H.
   Chem. Eur. J., 2021, 27, 4599-4604. doi.org/10.1002/chem.202003528
   Selected as a "Cover Feature"
10. "Quantitative Analyses of Forster Resonance Energy Transfer between Identical Pyrene Chromophores (Homo‐FRET) In DNA Scaffolds"
    Kashida, H.; Kawai, H.; Azuma, H.; Araki, Y.; Wada, T.; Asanuma, H.
    ChemPhotoChem, 2021, 5, 167-172. doi.org/10.1002/cptc.202000199
    Selected as a "Back Cover"

解説論文

1. "RNA以前に非環状型XNAがPre-RNAとして存在したか?"
   浅沼浩之, 沖田ひかり, 村山恵司
   Viva Origino, 2021, 49, 9. DOI: https://doi.org/10.50968/vivaorigino.49_9
   
2. "Pseudo Base Pairs that Exhibit High Duplex Stability and Orthogonality through Covalent and Non-covalent Interactions"
   Kashida, H.; Asanuma, H.
   J. Synth. Org. Chem. Jpn., 2021, 79, 1013-1019.
   
3. "光駆動型DNAナノマシン"
   浅沼浩之, 村山恵司, 神谷由紀子, 樫田　啓
   高分子, 2021, 70, 550-552.
   
4. "Design and Hybridization Properties of Acyclic Xeno Nucleic Acid Oligomers"
   Murayama, K.; Asanuma, H.
   ChemBioChem, 2021, 22, 2507-2515. doi.org/10.1002/cbic.202100184
   Selected as "Cover Feature"

著書

1. 「光応答性DNAの搭載によるナノマシンとナノ構造体の光制御」
   浅沼浩之, 神谷由紀子
   "進化を続ける核酸化学"　日本化学会編, 化学同人
   

2020

原著論文

1. "Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-aTNA/RNA and SNA/RNA"
   Kamiya, Y.; Satoh, T.; Kodama, A.; Suzuki, T.; Murayama, K.; Kashida, H.; Uchiyama, S.; Kato, K.; Asanuma, H.
   Commun. Chem., 2020, 3, 156. DOI: 10.1038/s42004-020-00400-2
   
2. "Investigation of strand selective interaction of SNA-modified siRNA with AGO2-MID"
   Kamiya, Y.; Takeyama, Y.; Mizuno, T.; Sato, F.; Asanuma, H.
   Int. J. Mol. Sci., 2020, 21, 5218. DOI: 10.3390/ijms21155218
   
3. "Photo-regulated trajectories of gliding microtubules conjugated with DNA"
   Akter, M.; Keya, J.J.; Kabir, A.M.R.; Asanuma, H.; Murayama, K.; Sada, K.; Kakugo, A.
   Chem. Commun., 2020, 56, 7953-7956. DOI: 10.1039/d0cc03124k
   
4. "A triplex-forming linear probe for sequence-specific detection of duplex DNA with high sensitivity and affinity"
   Chen, Y.; Murayama, K.; Kashida, H.; Kamiya, Y.; Asanuma, H.
   Chem. Commun., 2020, 56, 5358-5361. DOI: 10.1039/D0CC01865A
   Selected as a "Back Cover"
5. "Efficient Light-harvesting Antenna Results from Densely Organizing Dyes into a DNA Junction via D-threoninol"
   Kashida, H.; Azuma, H.; Maruyama, R.; Araki, Y.; Wada, T.; Asanuma, H.
   Angew. Chem. Int. Ed., 2020, 59, 11360-11363. DOI: 10.1002/anie.202004221
   
6. "Incorporation of Pseudo-complementary Bases 2,6-Diaminopurine and 2-Thiouracil into Serinol Nucleic Acid (SNA) to Promote SNA/RNA Hybridization"
   Kamiya, Y.; Sato, F.; Murayama, K.; Kodama, A.; Uchiyama, S.; Asanuma, H.
   Chem. Asian J., 2020, 15, 1266-1271. DOI: 10.1002/asia.201901728
   Selected as a "Cover Picture"
7. "A Quencher‐Free Linear Probe from Serinol Nucleic Acid with a Fluorescent Uracil Analogue"
   Murayama, K.; Asanuma, H.
   ChemBioChem, 2020, 21, 120-128. DOI: 10.1002/cbic.201900498
   Selected as a "Cover Feature"

解説論文

1. "核酸医薬の創製に向けた人工核酸の開発"
   樫田啓、村山恵司、浅沼浩之
   バイオマテリアル, 2020, 38(2), 124-129
   

著書

1. 「DNA機能の拡張」
   浅沼浩之
   “核酸化学ハンドブック”、編集；杉本直己、講談社（2020）

新聞記事

1. 核酸医薬への応用を目指した非環状型人工核酸の開発：科学新聞　2020年1月1日　4面
   浅沼浩之

2019

原著論文

1. "8-Pyrenylvinyl Adenine Controls Reversible Duplex Formation between Serinol Nucleic Acid and RNA by [2+2] Photocycloaddition"
   Murayama, K.; Yamano, Y.; Asanuma, H.
   J. Am. Chem. Soc., 2019, 141, 9485-9489. DOI: 10.1021/jacs.9b03267
   Selected as a "Supplementary Cover"
2. "Selective binding of nucleosides to gapped DNA duplex revealed by orientation and distance dependence of FRET"
   Kashida, H.; Kokubo, Y.; Makino, K.; Asanuma, H.
   Org. Biomol. Chem., 2019, 17, 6786-9789. DOI: 10.1039/C9OB00946A
   Selected as a "Front Cover"
3. "cis-on/trans-off of DNA hybridization with alkylthio-azobenzene on L-threoninol responding to visible light"
   Asanuma, H.; Ishikawa, T.; Yamano, Y.; Murayama, K.; Liang, X.
   ChemPhotoChem, 2019, 3, 418-424. DOI: 10.1002/cptc.201900060
   Selected as a "VIP"
   Selected as a "Cover Feature"
4. "Orthogonally Photocontrolled Non-Autonomous DNA Walker"
   Skugor, M.; Valero, J.; Murayama, K.; Centola, M.; Asanuma, H.; Famulok, M.
   Angew. Chem. Int. Ed., 2019, 58, 6948-6951. DOI: 10.1002/anie.201901272
5. "The Use of Serinol Nucleic Acids as Ultrasensitive Molecular Beacons"
   Murayama, K.; Kashida H.; Asanuma, H.
   Method in Molecular Biology, 2019, Vol. 1973, : Non-Natural Nucleic Acids.
6. "Isothermal double-cycle catalytic system using DNAzyme and RNase H for highly selective one-pot detection of oligonucleotides"
   An, R.; Kawai, H.; Asanuma, H.; Komiyama, M.; Liang, X.
   Analyst, 2019, 144, 2773-2779. DOI: 10.1039/c8an02520g
7. "In-stem molecular beacon targeted to a 5’-region of tRNA inclusive of the D arm that detects mature tRNA with high sensitivity"
   Miyoshi, Y.; Ohtsuki, T.; Kashida, H.; Asanuma, H.; Watanabe, K.
   PLOS ONE, 2019, 14(1), e0211505. DOI: 10.1371/journal.pone.0211505
8. "N-Benzoyl-Protected Peptide Nucleic Acid (PNA) Monomers Expand the Range of Nucleobases Available for PNA-DNA Chimera"
   Inagaki, M.; Uematsu, R.; Mizutani, T.; Unabara D.; Araki, Y.; Sakamoto, S.; Kashida, H.; Nishijima, M.; Inoue, Y.; Asanuma, H.; Wada, T.
   Chem. Lett., 2019, 48, 341-344. DOI: 10.1246/cl.181048
9. "Photo-regulatable DNA isothermal amplification by template-mediated ligation"
   Cheng, B.; Kashida, H.; Shimada, N.; Maruyama, A.; Asanuma, H.
   Chem. Commun., 2019, 55, 1080-1083. DOI: 10.1039/c8cc09218d

著書

1. "5.5 核酸の直交性"
   浅沼浩之、村山恵司
   "分子ロボティクス概論", 編集：村田 智, CBI学会出版 (2019)

2018

原著論文

1. "Quantitative evaluation of energy migration between identical chromophores enabled by breaking symmetry"
   Kashida, H.; Kawai, H.; Maruyama, R.; Kokubo, Y.; Araki, Y.; Wada, T.; Asanuma, H.
   Communications Chemistry, 2018, 1, 91.
2. "Bifacial nucleobases for hexaplex formation in aqueous solution"
   Kashida, H.; Hattori, Y.; Tazoe, K.; Inoue, T.; Nishikawa, K.; Ishii, K.; Uchiyama, S.; Yamashita, H.; Abe, M.; Kamiya, Y.; Asanuma, H.
   J. Am. Chem. Soc., 2018, 140, 8456-8462.
   Selected as a "Supplementary Journal Cover"
3. "Development of visible light-responsive RNA scissors based on the 10-23 DNAzyme"
   Kamiya, Y.; Arimura, Y.; Ooi, H.; Kato, K.; Liang, X.G.; Asanuma, H.
   ChemBioChem, 2018, 19, 1305-1311. DOI: 10.1002/cbic.201800020
4. "DNA-assisted swarm control in a biomolecular motor system"
   Keya, J.J.; Suzuki, R.; Kabir, A.M.R.; Inoue, D.; Asanuma, H.; Sada, K.; Hess, H.; Kuzuya, A.; Kakugo, A.
   Nat. Commun., 2018, 9, 453. DOI: 10.1038/s41467-017-02778-5

解説論文

1. "The DNA duplex as an aqueous one-dimensional soft crystal scaffold for photochemistry."
   Asanuma, H.; Murayama, K.; Kamiya, Y.; Kashida, H.
   Bull. Chem. Soc. Jpn., 2018, 91, 1739-1748.

著書

1. "ナノマテリアルとしての光応答性DNA"
   浅沼浩之、神谷由紀子
   "刺激応答性高分子ハンドブック"、監修：宮田　隆志、p.581-587、エヌ・ティー・エス(2018)
   

受賞

平成29年度日本化学会　学術賞
『非環状型核酸アナログによる機能性オリゴヌクレオチドの創製』

2017

原著論文

1. "DNA microcapsule for photo-triggered drug release system"
   Kamiya, Y.; Yamada, Y.; Muro, T.; Matsuura, K.; Asanuma, H.
   ChemMedChem, 2017, 12, 2016-2021. DOI: 10.1002/cmdc.201700512
   Selected as a "Front Cover"
2. "Introduction of 2,6-diaminopurines into serinol nucleic acid (SNA) improves anti-miRNA performance"
   Kamiya, Y.; Donoshita, Y.; Kamimoto, H.; Murayama, K.; Ariyoshi, J.; Asanuma, H.
   ChemBioChem, 2017, 18, 1917-1922
3. "Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes"
   Le, B. T.; Murayama, K.; Shabanpoor, F.; Asanuma, H.; Veedu, R. N.
   RSC Advances, 2017, 7, 34049-34052.
4. "D-aTNA circuit orthogonal to DNA can be operated by RNA input via SNA"
   Murayama, K.; Nagao, R.; Asanuma, H.
   ChemistrySelect, 2017, 2(20), 5624-5627.
5. "Chaperone polymer-assisted, photo-driven DNA strand displacement"
   Cheng, B.; Kashida, H.; Shimada, N.; Maruyama, A.; Asanuma, H.
   ChemBioChem, 2017, 18, 1568-1572. DOI: 10.1002/cbic.201700394
   Selected as a "Front Cover"
6. "Orientation-dependent FRET system reveals differences in structures and flexibilities of nicked and gapped DNA duplexes"
   Kashida, H.; Kurihara, A.; Kawai, H.; Asanuma, H.
   Nucleic Acids Res., 2017, 45(11), e105
7. "Effect of Methyl Group on Acyclic Serinol Scaffold for Tethering Dyes on DNA Duplex stability"
   Murayama, K.; Asanuma, H.
   ChemBioChem, 2017, 18, 142-149

解説論文

　　　
1. "生細胞内RNAイメージングのための人工核酸"
   樫田啓、浅沼浩之
   生体の科学, 2017, 68(5), 440-441
2. "光応答性DNAの開発―ナノ環境を汚染しない分子マシンへの応用―"
   浅沼浩之
   現代化学, 2017, 556(7), 50-55
3. "Development of pseudo base-pairs on D-threoninol which exhibit various functions."
   Kashida, H.; Asanuma, H.
   Bull. Chem. Soc. Jpn., 2017, 90, 475
4. "DNA二重鎖による色素会合体の精密位置配向制御と光化学への展開"
   浅沼浩之、樫田啓
   固体物理, 2017, 52(3), 149-158
5. "DNA二重鎖の高い安定性と直交性をもつ疑似塩基対の開発"
   樫田啓、浅沼浩之
   高分子論文集, 2017, 74(4)257-264.
6. "Design of photo-functional oligonucleotide by "copolymerization" of natural nucleobases with base-surrogate prepared from acyclic scaffold."
   Asanuma, H.; Murayama, K.; Kamiya, Y.; Kashida, H.
   Polymer J., 2017, 49, 279-289

著書

1. "遺伝子を蛍光検出するナノプローブ開発"
   浅沼浩之、樫田 啓
   "ナノテクノロジーが拓く未来の医療"、片岡一則　編著、2017年12月25日発行、丸善プラネット（株）
   

2016

原著論文

1. "Dynamics of Inter-DNA Chain Interaction of Photoresponsive DNA"
   Nakasone, Y.; Ooi, H.; Kamiya, Y.; Asanuma, H.; Terazima, M.
   J. Am. Chem. Soc., 2016, 138, 9001-9004
2. "Strand-invading linear probe combined with unmodified PNA"
   Aasanuma, H.; Niwa, R.; Akahane, M.; Murayama, K.; Kashida, H.; Kamiya, Y.
   Bioorg. Med. Chem., 2016, 24, 4129-4137. DOI:10.1016/j.bmc.2016.06.055
   
3. "Visible Light-Triggered Crosslinking of DNA Duplex by Reversible [2+2] Photocycloaddition of Styrylpyrene"
   Doi, T.; Kawai, H.; Murayama, K.; Kashida, H.; Asanuma, H.
   Chem. Eur. J., 2016, 22, 10533-10538
4. "A stem-less probe using spontaneous pairing between Cy3 and quencher for RNA detection"
   Kashida, H.; Morimoto, K.; Asanuma, H.
   Sci. Technol. Adv. Mater., 2016, 17, 267-273
5. "Faint electric treatment-induced rapid endosomal escape for efficient delivery of functional macromolecules into the cytoplasm"
   Hasan, M.; Nishimoto, A.; Ohgita, T.; Hama, S.; Kashida, H.; Asanuma, H.; Kogure, K.
   J. Control Release, 2016, 228, 20-25
   

解説論文

1. "Acyclic artificial nucleic acids with phosphodiester bonds exhibit unique functions"
   Kashida, H.; Murayama, K.; Asanuma, H.
   Polymer J., 2016, 48, 781-786
2. "天然に存在しない非環状構造の核酸アナログ-人工の非環状骨格で神の設計した環状骨格に挑む"
   村山恵司、浅沼浩之
   化学, 2016, 71(3), 66-67
   

著書

1. "非環状骨格型人工核酸：aTNA, SNA"
   神谷由紀子、村山恵司、樫田 啓、浅沼浩之
   "核酸医薬の創製と応用展開", 監修：和田 猛, p79-86, シーエムシー出版, (2016)
   

受賞

平成27年度高分子学会賞(科学)
『非環状型人工核酸による光機能性ナノマテリアルの創製』

2015

原著論文

1. "Terminus-free siRNA prepared by photo-crosslinking activated via slicing by Ago2"
   Kamiya, Y.; Iishiba, K.; Doi. T.; Tsuda, K.; Kashida, H.; Asanuma, H.
   Biomater. Sci., 2015, 3, 1534-1538
   Selected as a "Back cover"
2. "Azobenzene C-nucleosides for photo-controlled hybridization of DNA at room temperature"
   Goldau, T.; Murayama, K.; Brieke, C.; Asanuma, H., Heckel, A.
   Chem. Eur. J., 2015, 21, 17870-17876, DOI : 10.1002/chem.201503303
   
3. "Hetero-Selective DNA-like Duplex Stabilized by Donor-Acceptor Interaction"
   Doi, T.; Sakakibara,T.; Kashida, H.; Araki, Y.; Wada, T.; Asanuma, H.
   Chem. Eur. J., 2015, 21, 15974-15980. DOI:10.1002/chem.201502653
   Selected as a "Frontispiece"
4. "Ultra-Sensitive Molecular Beacon Designed with Totally Serinol Nucleic Acid (SNA) for Monitoring mRNA in Cell"
   Murayama, K.; Kamiya, Y.; Kashida, H.; Asanuma, H.
   ChemBioChem, 2015, 16, 1298-1301, DOI: 10.1002/cbic.201500167
   
5. "Molecular design of Cy3 derivative for highly sensitive in-stem molecular beacon and its application to the wash-free FISH"
   Kashida, H.; Osawa, T.; Morimoto, K.; Kamiya, Y.; Asanuma, H.
   Bioorg. Med. Chem., 2015, 23, 1758-1762
6. "Efficiency of [2+2] photodimerization of various stilbene derivatives within the DNA duplex scaffold"
   Doi, T.; Kashida, H.; Asanuma, H.
   Org. Biomol. Chem., 2015, 13, 4430-4437
   Selected as a "Front Cover"
7. "Highly sensitive and robust linear probe for detection of mRNA in cells"
   Asanuma, H.; Akahane, M.; Niwa, R.; Kashida, H.; Kamiya, Y.
   Angew. Chem. Int. Ed., 2015, 54, 4315-4319
8. "Acyclic L-Threoninol Nucleic Acid (L-aTNA) with Suitable Structural Rigidity Cross-pairs with DNA and RNA."
   Murayama, K.; Kashida, H.; Asanuma, H.
   Chem. Commun., 2015, 51, 6500-6503
   Selected as a "Back Cover"
9. "Reversible photoswitching of RNA hybridization at room temperature with an azobenzene C-nucleoside."
   Goldau, T.; Murayama, K.; Brieke, C. Steinwand, S.; Mondal, P.; Biswas, M.; Burghardt, I.; Wachtveitl, J.; Asanuma, H.; Heckel, A.
   Chem. Eur. J., 2015, 21, 2845-2854
10. "Synthetic gene involving azobenzene-tethered T7 promoter for the photocontrol of gene expression by visible light."
    Kamiya, Y.; Takagi, T.; Ooi, H.; Ito, H.; Liang, X.G.; Asanuma, H.
    ACS Synth. Biol., 2015, 4, 365-370.

解説論文

1. "Pre-organized guide RNA in Cas9 complex is ready for selection of the target double-stranded DNA"
   Kamiya, Y.; Asanuma, H.
   ChemBioChem, in press, DOI: 10.1002/cbic.201500424
   
2. "Reversible photo-switching of DNA fuction with azobenzene-tethered DNA"
   Kamiya, Y.; Asanuma, H.
   The Glen Report, 2015, 27, 1-3
   
3. "新規人工核酸SNAを用いたRNAイメージング"
   樫田 啓、村山恵司、浅沼浩之
   生体の科学 2015, 66(2), 145-150
   

2014

原著論文

1. "Highly specific DNA detection from massive background nucleic acids based on rolling circle amplification of target dsDNA"
   Wang, X.; Yu, X.; Wand, X.; Suzuki, M.; Asanuma, H.; Dong, P.; Wu, W.; Liang, X.G.
   RSC Adv., 2014, 4, 38293-38299.
2. "Enhancement of stability and activity of siRNA by terminal substitution with Serinol Nucleic Acid (SNA)."
   Kamiya, Y.; Takai, J.; Ito, H.; Murayama, K.; Kashida, H.; Asanuma, H.
   ChemBioChem, 2014, 15, 2549-2555.
   Selected as a "Back Cover"

解説論文

1. "DNA二重鎖を足場とした配向依存的FRET"
   浅沼浩之、栗原綾子、樫田啓
   光化学 2014, 45, 146-147
   
2. "De Novo Design of Functional Oligonucleotides with Acyclic Scaffolds"
   Asanuma, H.; Kashida, H.; Kamiya, Y.
   Chem. Rec. 2014, 14, 1055-1069.
3. "Light-driven DNA nanomachine with a photoresponsive molecular engine."
   Kamiya, Y.; Asanuma, H.
   Accounts of Chemical Research, 2014, 47, 1663-1672.

2013

原著論文

1. "Selective labeling of mature RISC using siRNA carrying fluorophore-quencher pair."
   Kamiya, Y.; Ito, A.; Ito, H.; Urushihara, M.; Takai, J.; Fujii, T.; Liang, X.G.; Kashida, H.; Asanuma, H.
   Chem. Sci., 2013, 4, 4016-4021.
2. "The “sugar-deficient” G-quadruplex: incorporation of aTNA in quadruplex structures."
   Zhou, J.; Murayama, K.; Amrane, S.; Kashida, H.; Bourdoncle, A.; Asanuma, H.; Mergny, J. L.
   Chem. Sci., 2013, 4, 3693-3698.
3. "Highly stable duplex formation by artificial nucleic acids aTNA and SNA with acyclic scaffolds."
   Murayama, K.; Tanaka, Y.; Toda, T.; Kashida, H.; Asanuma, H.
   Chem. Eur. J., 2013, 19, 14151-14158.
4. "p-Stilbazole moieties as artificial base pairs for photocrosslinking of DNA duplex."
   Kashida, H.; Doi, T.; Sakakibara, T.; Hayashi, T.; Asanuma, H.
   J. Am. Chem. Soc., 2013, 135, 7960-7966.
5. "Evaluation of intrinsic spectroscopic properties of chromophore assemblies by shielding with cyclohexyl base pairs within a DNA duplex."
   Kashida, H.; Higashiyama, N.; Kato, T.; Asanuma, H.
   Bioorg. Med. Chem., 2013, 21, 6191-6197.
6. "Photoswitch nucleic acid catalytic activity by regulating topological structure with a universal supra-photoswitch"
   Liang, X.G.; Zhou, M.G.; Kato, K.; Asanuma, H.
   ACS Synth. Biol., 2013, 2, 194-202.
7. "Development of a robust model system of FRET using base-surrogates tethering fluorophores for strict control of their position and orientation within DNA duplex."
   Kato, T.; Kashida, H.; Kishida, H.; Yada, H.; Okamoto, H.; Asanuma, H.
   J. Am. Chem. Soc., 2013, 135, 741-750.

著書

1. "ナノ環境に優しい光応答性DNAの設計"
   神谷由紀子、浅沼浩之
   "太陽エネルギー社会を築く材料テクノロジー（I)　-材料・デバイス編-"
   名古屋大学大学院工学研究科 材料バックキャストテクノロジー研究センター　編
   p.192-210, コロナ社 (2013).

2012

原著論文

1. "A model of elongation of short DNA sequence by thermophilic DNA polymerase under isothermal conditions."
   Kato, T.; Liang, X. G.; Asanuma, H.
   Biochemistry, 2012, 51, 7846-7853.
2. "Reversed assembling of dyes in RNA duplex compared with those in DNA"
   Fujii, T.; Urushihara, M.; Kashida, H.; Ito, H.; Liang, X.G.; Yagi-Utsumi, M.; Kato, K.; Asanuma, H.
   Chem. Eur. J., 2012, 18, 13304-13313.
   Selected as a "frontispiece"
3. "Quencher-free linear probe with multiple fluorophores on acyclic scaffold"
   Asanuma, H.; Akahane, M.; Kondo, N.; Osawa, T.; Kato, T.; Kashida, H.
   Chem. Sci., 2012, 3, 3165-3169.
   Selected as an "Inside Back Cover"
4. "Bulge-like asymmetric hetero dye-clustering in DNA duplex results in efficient quenching of background emission based on the maximized excitonic interaction"
   Fujii, T.; Hara, Y.; Osawa, T.; Kashida, H.; Liang, X.G.; Yoshida, Y.; Asanuma, H.
   Chem. Eur. J., 2012, 18, 10865-10872.
5. "Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation"
   Kashida, H.; Yamaguchi K.; Hara, Y.; Asanuma, H.
   Bioorg. Med. Chem., 2012, 20, 4310-4315.
6. "Coherent Interactions of Dyes Assembled on DNA" (Review)
   Asanuma, H.; Fujii, T.; Kato, T.; Kashida, H.
   J. Photochem. Photobiol. C, 2012, 13, 124-135.
7. "Preparation of supramolecular chromophoric assemblies using a DNA duplex" (Perspective)
   Kashida, H.; Asanuma, H.
   Phys. Chem. Chem. Phys., 2012, 14, 7196-7204.
8. "Design of an Artificial Functional Nanomaterial with High Recognition Ability"
   Liang, X. G.; Mochizuki, T.; Fujii, T.; Kashida, H.; Asanuma, H.
   Natural Computing, 2012, 11, 231-238.
9. "Improvement of RNAi activity and strand-selectivity of RISC formation by modified siRNA involving intercalators near 5'-termini"
   Ito, H.; Urushihara, M.; Liang, X. G.; Asanuma, H.
   ChemBioChem, 2012, 13, 311-315.
10. "Polycation-chaperoned in-stem molecular beacon system"
    Asanuma, H.; Osawa, T.; Kashida, H.; Fujii, T.; Liang, X. G.; Niwa, K.; Yoshida, Y.; Shimada, N.; Maruyama, A.
    Chem. Commun., 2012, 48, 1760-1762.
11. "Photon-fueled DNA nanodevice carrying two different photoswitches."
    Nishioka, H.; Liang, X. G.; Kato, T.; Asanuma, H.
    Angew. Chem. Int. Ed., 2012, 51, 1165-1168.
12. "Ultrafast photoisomerization and its single-shot pump pulse efficiency of trans-azobenzene derivative: Compound for photosensitive DNA."
    Chen, T.; Yamaguchi, A.; Igarashi, K.; Nakagawa, N.; Nishioka, H.; Asanuma, H.; Yamashita, M.
    Opt. Commun., 2012, 285, 1206-1211.

著書

1. "Oligonucleotide Conjugates for Detection of Specific Nucleic Acid Sequences"
   Kashida, H.; Asanuma, H.
   "DNA Conjugates and Sensors" Eds. by K. R. Fox, T. Brown
   RSC Publishing, p.242-257, (2012).

2011

原著論文

1. "Cyclohexyl “base pairs” stabilize duplexes and intensify pyrene fluorescence by shielding it from natural base pairs."
   Kashida, H.; Sekiguchi, K.; Higashiyama, N.; Kato, T.; Asanuma, H.
   Org. Biomol. Chem., 2011, 9, 8313-8320.
2. "Femtosecond photoisomerization of azobenzene-derivative binding to DNA."
   Chen, T.; Igarashi, K.; Nakagawa, N.; Yamane, K.; Fujii, T.; Asanuma, H.; Yamashita, M.
   J. Photochem. Photobiol. A, 2011, 223, 119-123.
3. "Nick Sealing by T4 DNA Ligase on a Modified DNA Template Tethering a Functional Molecule on D-Threoninol."
   Liang, X. G.; Fujioka, K.; Asanuma, H.
   Chem. Eur. J., 2011, 17, 10388-10396.
4. "Preparation of photoresponsive DNA tethering ortho-methylated azobenzene as a supraphotoswitch."
   Asanuma, H.; Nishioka, H.; Ishikawa, T.; Liang, X. G.;
   Current Protocols in Nucleic Acid Chemistry, 2011, 4.45.1-4.45.18.(DOI: 10.1002/0471142700.nc0445s46)
5. "Detection of three-base deletion by exciplex formation with perylene derivatives."
   Kashida, H.; Kondo, N.; Sekiguchi, K.; Asanuma, H.
   Chem. Commun., 2011, 47, 6404-6406.
6. "A Cationic dye triplet as a unique “glue” that can connect fully matched termini of DNA duplexes."
   Kashida, H.; Hayashi, T.; Fujii, T.; Asanuma, H.
   Chem. Eur. J., 2011, 17, 2614-2622.
   Selected as a "VIP"
   Selected as an "Inside Cover"
7. "Control of the Chirality and Helicity of Oligomers of Serinol Nucleic Acid (SNA) by Sequence Design."
   Kashida, H.; Murayama, K.; Toda, T.; Asanuma, H.
   Angew. Chem. Int. Ed., 2011, 50, 1285-1288.
   Selected as a "Hot Paper"
8. "Design of a Functional Nanomaterial with Recognition Ability for Constructing Light-Driven Nanodevices."
   Liang, X.G.; Mochizuki, T.; Fujii, T.; Kashida, H.; Asanuma, H.
   LNCS 2011, 6518, 112-122.

著書

1. "カートリッジ型人工ヌクレオチドによる光応答性ＤＮＡの設計"
   浅沼浩之、梁興国
   "核酸化学のニュートレンド"、日本化学会　編、p.56-62、化学同人(2011)

2010

原著論文

1. "Unexpectedly stable artificial duplex from flexible acyclic threoninol."
   Asanuma, H.; Toda, T.; Murayama, K.; Liang, X.G.; Kashida, H.
   J. Am. Chem. Soc., 2010, 132, 14702-14703.
2. "Construction of photoresponsive RNA for photoswitching RNA hybridization."
   Ito, H.; Liang, X.G.; Nishioka, H.; Asanuma, H.
   Org. Biomol. Chem., 2010, 8, 5519-5524.
3. "Robust and photo-controllable DNA capsules using azobenzenes."
   Tanaka, F.; Mochizuki, T.; Liang, X.G.; Asanuma, H.; Tanaka, S.; Suzuki, K.; Kitamura, S.; Nishikawa, A.; Ui-Tei, K.; Hagiya, M.
   Nano Lett., 2010, 10, 3560-3565.
4. "Insulator base pairs for lighting-up perylenediimide in a DNA duplex."
   Kashida, H.; Sekiguchi, K.; Asanuma, H.
   Chem. Eur. J., 2010, 16, 11554-11557.
5. "Coherent Quenching of a Fluorophore for the Design of a Highly Sensitive In-Stem Molecular Beacon."
   Hara, Y.; Fujii, T.; Kashida, H.; Sekiguchi, K.; Liang, X. G.; Niwa, K.; Takase, T.; Yoshida, Y.; Asanuma, H.
   Angew. Chem. Int. Ed., 2010, 49, 5502-5506.
6. "Accumulation of fluorophores into DNA duplexes to mimic the properties of quantum dots."
   Kashida, H.; Sekiguchi, K.; Liang, X. G.; Asanuma, H.
   J. Am. Chem. Soc., 2010, 132, 6223-6230.
7. "Photoregulation of DNA transcription by using photoresponsive T7 promoters and clarification of its mechanism."
   Liang, X.G.; Wakuda, R.; Fujioka, K.; Asanuma, H.
   FEBS J. 2010, 277, 1551-1561.
   Selected as "Front Cover"
8. "A light-driven DNA nanomachine for efficiently photoswitching RNA digestion."
   Zhou M.G.; Liang, X.G.; Mochizuki, T.; Asanuma, H.
   Angew. Chem. Int. Ed. 2010, 49, 2167-2170.
   Selected as "Hot paper"
   Highlighted in Chemistry World
   Highlighted in Nature, 2010, 464, 10.
9. "Effect of the ortho modification of azobenzene on the photoregulatory efficiency of DNA hybridization and thermal stability of its cis-form."
   Nishioka H.; Liang, X.G.; Asanuma, H.
   Chem. Eur. J. 2010, 16, 2054-2062.
10. "An efficient Fluorescent Resonance Energy Transfer (FRET) between pyrene and perylene assembled in a DNA duplex and its potential for discriminating single base changes."
    Kashida, H.; Takatsu,T.; Sekiguchi, K.; Asanuma, H.
    Chem. Eur. J., 2010, 16, 2479-2486.
11. "An interstrand-wedged duplex composed of alternating DNA base pairs and covalently attached intercalators."
    Liang, X.G.; Nishioka H.; Mochizuki, T.; Asanuma, H.
    J. Mater. Chem. 2010, 20, 575-581.
12. "Molecular imprinting of cyclodextrin to physiologically active oligopeptides in water."
    Song, S.H.; Shirasaka, K.; Hirokawa, Y.; Asanuma, H.; Wada, T.; Sumaoka, J.; Komiyama, M.
    Supramol. Chem. 2010, 22, 149-155.

著書

1. "人工核酸を利用したプローブDNAの調製と遺伝子多型検出"
   樫田啓、浅沼浩之
   "バイオチップ実用化ハンドブック"、金子周一　堀池靖浩　監修、p.603-610、エヌ・ティー・エス(2010)

2009

原著論文

1. "In-Stem Molecular Beacon containing a Pseudo Base Pair of Threoninol Nucleotides for the Removal of Background Emission."
   Kashida, H.; Takatsu, T.; Fujii, T.; Sekiguchi, K.; Liang, X. G.; Niwa, K.; Takase, T.; Yoshida, Y.; Asanuma, H.
   Angew. Chem. Int. Ed., 2009, 48, 7044-7047.
2. "Modulation of pKa of Brooker’s Merocyanine by DNA Hybridization."
   Kashida, H.; Sano, K.; Hara, Y.; Asanuma, H.
   Bioconjugate Chem., 2009, 20, 258-265.
3. "Photoisomerization dynamics study on cis-azobenzene derivative using ultraviolet-to-visible tunable femtosecond pulses."
   Yamaguchi, N.; Nagasawa, N.; Igarashi, K.; Sekikawa, T.; Nishioka, H.; Asanuma, H.; Yamashita, M.
   Appl. Surf. Sci. 2009, 255, 9864-9868.
4. "A Supra-Photoswitch Involving Sandwiched DNA Base Pairs and Azobenzenes for Light-Driven Nanostructures and Nanodevices."
   Liang, X.G.; Mochizuki, T.; Asanuma, H.
   Small 2009, 5, 1761-1768.
   Selected as "Front Cover"
5. "Construction of Photon-Fueled DNA Nanomachines by Tethering Azobenzenes as Engines."
   Liang, X.G.; Nishioka, H.; Takenaka, N.; Asanuma, H.
   LNCS 2009, 5347, 21-32.
6. "Analysis of Coherent Heteroclustering of Different Dyes by Use of Threoninol Nucleotides for Comparison with the Molecular Exciton Theory."
   Fujii, T.; Kashida H.; Asanuma, H.
   Chem. Eur. J., 2009, 15, 10092-10102.
7. "Positively charged base surrogate for highly stable “base pairing” through electrostatic and stacking interactions."
   Kashida, H.; Ito, H.; Fujii, T.; Hayashi, T.; Asanuma, H.
   J. Am. Chem. Soc., 2009, 131, 9928-9930.
8. "Glucuronidase-assisted transglycosylation for the synthesis of highly functional disaccharides: β-D-Glucuronyl 6-O-sulfo-β-D-gluco- and -β-D-Galactopyranosides."
   Nagatsuka T.; Uzawa H.; Asanuma, H., Nishida, Y.
   J. Carbohydrate Chem. 2009, 28, 94-106.
9. "Efficient energy transfer from pyrene to perylene assembled inside DNA duplex."
   Kashida, H.; Takatsu, T.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2009, 53, 29-30.
10. "Line up base pairs and intercalators one by one in a stable duplex."
    Liang, X.G.; Mochizuki T.; Nishioka H.; Asanuma, H.
    Nucleic Acids Symp. Ser. 2009, 53, 189-190.

解説論文

1. "ＤＮＡを切断するはさみ"
   西岡英則、浅沼浩之
   化学, 2009, 64, 70-71.
2. "Rational design of functional DNA with a non-ribose acyclic scaffold"
   Kashida, H.; Liang, X.G.; Asanuma, H.
   Curr. Org. Chem., 2009, 13, 1065-1084.

著書

1. "DNAのダイナミックな光制御"
   浅沼浩之、梁興国
   "超分子サイエンス＆テクノロジー　―基礎からイノベーションまで―"、国武豊喜　監修、p.941-948、エヌ・ティー・エス(2009)

2008

原著論文

1. "Postsynthetic modification of DNA via threoninol on a solid support by means of allylic protection."
   Asanuma, H.; Hara, Y.; Noguchi, A.; Sano, K.; Kashida, H.
   Tetrahedron Lett.., 2008, 49, 5144-5146.
2. "A DNA Nanomachine Powered by Light Irradiation."
   Liang, X.G.; Nishioka, H.; Takenaka, N.; Asanuma, H.
   ChemBioChem, 2008, 9, 702-705.
3. "Molecular Design for Reversing the Photoswitching Mode of Turning ON and OFF DNA Hybridization"
   Liang, X.G.; Takenaka, N.; Nishioka, H.; Asanuma, H.
   Chem. Asian J., 2008, 3, 553-560.
4. "Threoninol as a Scaffold of Dyes (Threoninol-nucleotide) and Their Stable Interstrand Clustering in Duplexes."
   Kashida, H.; Fujii, T.; Asanuma, H.
   Org. Biomol. Chem., 2008, 6, 2892-2899.
5. "Diastereomer Separation of Azobenzene-Tethered Oligodeoxyribonucleotides and Determination of Their Absolute Configurations by Enzymatic Digestion."
   Liang, X. G.; Komiyama, M.; Asanuma, H.
   Nucleosides, Nucleotides & Nucleic Acids, 2008, 27, 332-350.
6. "Construction of a photo-switchable gene for turning on and off gene expression with light irradiation."
   Liang, X.G.; Fujioka, K.; Tsuda, Y.; Wakuda, R.; Asanuma, H.
   Nucleic Acids Symp. Ser. 2008, 52, 19-20.
7. "Light driven open/close operation of an azobenzene-modified DNA nano-pincette."
   Liang, X.G.; Takenaka, N.; Nishioka, H.; Asanuma, H.
   Nucleic Acids Symp. Ser. 2008, 52, 697-698.
8. "Incorporation of cationic dyes into DNA for distinct stabilization of duplex"
   Kashida, H.; Itoh, H.; Fujii, T.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2008, 52, 701-702.
9. "Preparation of coherent hetero clusters with threoninol scaffold."
   Fujii, T.; Kashida, H.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2008, 52, 699-700.

2007

原著論文

1. "Detection of genetic polymorphisms with high sensitivity by DNA-perylene conjugate."
   Kashida, H.; Takatsu, T.; Asanuma, H.
   Tetrahedron Lett., 2007, 48, 6759-6762.
2. "Recognition of Solution Structures of Peptides by Molecularly Imprinted Cyclodextrin Polymers."
   Song, S.; Shirasaka, K.; Katayama, M.; Nagaoka, S.; Yoshihara, S.; Osawa, T.; Sumaoka, J.; Asanuma, H., Komiyama, M.
   Macromolecules 2007, 40, 3530-3532.
3. "2',6'-Dimethylazobenzene as an efficient and thermo-stable photo-regulator for the photoregulation of DNA hybridization."
   Nishioka, H.; Liang, X.G.; Kashida, H.; Asanuma, H.
   Chem. Commun., 2007, 4354-4356.
4. "Synthesis of Azobenzene-Tethered DNA for Reversible Photo-Regulation of DNA."
   Asanuma, H.; Liang, X.G.; Nishioka, H.; Matsunaga, D.; Liu, M.Z.; Komiyama, M.
   Nat. Protoc., 2007, 2, 203-212.
5. "Development of high-sensitive DNA probe by using perylene."
   Kashida, H.; Takatsu, T.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2007, 51, 279-280.
6. "Construction of novel dye aggregates based on "comb-type" sequence."
   Kashida, H.; Fujii, T.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2007, 51, 11-12.
7. "Preparation of "comb-type" hetero aggregates by DNA-dye conjugation."
   Fujii, T.; Kashida, H.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2007, 51, 277-278.
8. "Photoregulation of DNA hybridization by introducing an azobenzene: Molecular design for more stabilization of DNA duplex with cis-azobenzene than with its trans-form."
   Liang, X.G.; Takenaka, N; Nishioka, H.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2007, 51, 169-170.
9. "Unexpected efficient ab initio DNA synthesis at low temperature by using thermophilic DNA polymerase."
   Liang, X.G.; Kato, T.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2007, 51, 351-352.
10. "Effective photoregulation of gene expression by photoresponsive T7 promoter."
    Liang, X.G.; Wakuda, R.; Tsuda, Y.; Nishioka, H.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 349-350.
11. "Development of photoresponsive RNA towards photoswitching of RNA functions."
    Ito, H.; Nishioka, H.; Liang, X.G.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 171-172.
12. "Design of peptide nucleic acid by introduction of carbohydrate on lysine linker."
    Noguchi, A.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 261-262.

2006

原著論文

1. "Covalent Incorporation of Methyl Red Dyes into Double-Stranded DNA for Their Ordered Clustering"
   Kashida, H.; Tanaka, M.; Baba, S.; Sakamoto, T.; Kawai, G.; Asanuma, H.; Komiyama, M.
   Chem. -Eur. J., 2006, 12, 777-784.
2. "Exciplex Formation between Pyrene and N,N-Dimethylaniline in DNA for the Detection of One-base Deletion."
   Kashida, H.; Komiyama, M.; Asanuma, H.
   Chem. Lett., 2006, 35, 934-935.
3. "Insertion of two pyrene moieties into oligodeoxyribonucleotides for the efficient detection of deletion polymorphisms."
   Kashida, H.; Asanuma, H.; Komiyama, M.
   Chem. Commun., 2006, 2768-2770.
   (Highlighted in Chemical Biology, B29, 1 (2006))
4. "Photo- and Thermoregulation of DNA Nanomachines."
   Takahashi, K.; Yaegashi, S.; Asanuma, H.; Hagiya, M.
   LNCS 2006, 3892, 336-346.
5. "Azobenzene-tethered T7 promoter for Efficient Photoregulation of Transcription."
   Liu, M.; Asanuma, H.; Komiyama, M.
   J Am. Chem. Soc., 2006, 128, 1009-1015.
6. "Enhancement of RNA Cleavage Activity of 10-23 DNAzyme by Covalently Introduced Intercalator."
   Asanuma, H.; Hayashi, H.; Zhao, J.; Liang, X.G.; Yamazawa, A.; Kuramochi, T.; Matsunaga, D.; Aiba, Y.; Kashida, H.; Komiyama, M.
   Chem. Commun., 2006, 5062-5064.
7. "Improved Method of Molecular Imprinting of Cyclodextrin on Silica-gel Surface for the Preparation of Stable Stationary HPLC Phase."
   Matsui, T.; Osawa , T.; Shirasaka , K.; Katayama, M.; Hishiya, T.; Asanuma, H., Komiyama, M.
   J. Inclu. Phenom. Macrocyclic Chem. 2006, 56, 39-44.
8. "Importance of the position of vinyl group on beta-cyclodextrin for the effective imprinting of amino acid derivatives and oligopeptides in water."
   Osawa, T.; Shirasaka, K.; Matsui, T.; Yoshihara, S.; Akiyama, T.; Hishiya, T.; Asanuma, H.; Komiyama, M.
   Macromolecules, 2006, 39, 2460-2466.
9. "Incorporation of Methyl Group on Azobenzene for the Effective Photo-Regulation of Hybridization and Suppression of Thermal Isomerization."
   Nishioka, H.; Kashida, H.; Komiyama, M.; Liang, X.G.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2006, 50, 85-86.
10. "Activation of DNA Enzyme 10-23 by Tethering an Intercalator to Its Backbone."
    Hayashi, H.; Liang, X.G.; Zhao, J.; Komiyama, M.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2006, 50, 167-168.

著書

1. "光機能化ＤＮＡファイバー"
   浅沼浩之
   "”ファイバー”スーパーバイオミメティックス"、本宮達也　監修、p.488-492、エヌ・ティー・エス(2006)

2005

原著論文

1. "Clear-cut photo-regulation of the formation and dissociation of the DNA duplex by modified oligonucleotide involving multiple azobenzenes"
   Asanuma, H.; Matsunaga, D.; Komiyama, M.
   Nucleic Acids Symp. Ser., 2005 49 35-36.
2. "Design of Light-switchable Phage Promoter for Efficient Photo-regulation of Gene-expression"
   Liu, M.; Komiyama, M.; Asanuma, H.
   Nucleic Acids Symp. Ser., 2005 49 283-284.

解説論文

1. "バイオナノデバイスとしての人工DNA"
   浅沼浩之
   化学と教育, 2005, 53, 12-15.

著書

1. "光による核酸機能の制御"
   "高分子新素材の全て"、国武豊喜　監修、p.50-54、工業調査会(2005)

2004

原著論文

1. "Alternating hetero H-aggregation of different dyes by interstrand stacking from two DNA-dye conjugates"
   Kashida, H.; Asanuma, H.; Komiyama, M.
   Angew. Chem. Int. Ed., 2004, 43, 6522-6525.
2. "Interstrand H aggregation of cationic dyes for narrowing the absorption spectra and stabilizing the duplex"
   Kashida, H.; Asanuma, H.; Komiyama, M.
   Supramol. Chem., 2004, 16, 459-464.
3. "Efficient Separation of Hydrophobic Biomolecules by Molecularly Imprinted Cyclodextrins."
   Asanuma, H.; Hishiya, T.; Komiyama, M.
   J. Inclu. Phenom. Macrocyclic Chem., 2004, 50, 51-55.
4. "Photo-regulation of RNA Digestion by RNase H with Azobenzene-Tethered DNA"
   Matsunaga, D.; Asanuma, H.; Komiyama, M.
   J. Am. Chem. Soc., 2004, 126, 11452-11453.
5. "Real time monitoring of the interaction of T7 RNA polymerase with azobenzene-tethered T7 promoter by biosensor",
   Liu, M.; Asanuma, H.; Komiyama, M.
   Nucleic Acids Res. Suppl., 2004, 221-222.
6. "Photoregulation of in vitro transcription/translation of GFP by tethering an azobenzene to T7 promoter."
   Zhao, J.; Zhou, J.; Liu, M.; Asanuma, H.; Komiyama, M.
   Nucleic Acids Res. Suppl., 2004, 4, 199-20

解説論文

1. "インプリント・シクロデキストリン高分子による分子認識"
   小宮山真、白坂和美、浅沼浩之
   高分子加工, 2004, 53(11), 497-501.
2. "光機能性DNAの設計と応用"
   浅沼浩之、樫田啓
   高分子加工, 2004, 53(1), 37-43.

2003

原著論文

1. "DNA-Dye conjugates for controllable H* aggregation"
   Asanuma, H.; Shirasuka, K.; Takarada, T.; Kashida, H.; Komiyama, M.
   J. Am. Chem. Soc., 2003, 125, 2217-2223.
2. "Molecularly Imprinted Cyclodextrin Polymers as Stationary Phases of High Performance Liquid Chromatography"
   Hishiya, T.; Asanuma, H.; Komiyama, M.
   Polymer J., 2003, 35, 440-445.
3. "Synergistic Effect of the Two Azobenzenes in the Promoter on the Photo-Regulation of Transcription Reaction with SP6 RNA Polymerase"
   Liu, M.; Tamaru, D.; Asanuma, H.; Komiyama, M.
   Chem. Lett., 2003, 32, 1174-1175.
4. "NMR study on the Photo-responsive DNA Tethering an Azobenzene. Assignment of the Absolute Configuration of Two Diastereomers and Structure Determination of their Duplexes in the trans-Form."
   Liang, X.; Asanuma, H.; Kashida, H.; Takasu, A.; Sakamoto, T.; Kawai, G.; Komiyama, M.
   J. Am. Chem. Soc., 2003, 125, 16408-16415.
5. "DNA-Naphthyl Red conjugate as a visualizing probe of DNA hybridization"
   Asanuma, H.; Kashida, H.; Liang, X.; Komiyama, M.
   Chem. Commun., 2003, 1536-1537.
6. "Development of a probe DNA which accompanies color change by hybridization"
   Kashida, H.; Asanuma, H.; Komiyama, M.
   Nucleic Acids Res. Suppl., 2003, 3, 143-144.
7. "Effective photo-regulation of transcription reaction by SP6 RNA polymerase with modified DNA tethering multiple azobenzenes"
   Liu, M.; Asanuma, H.; Komiyama, M.
   Nucleic Acids Res. Suppl., 2003, 3, 265-266.
8. "Photo-regulation of DNA function by azobenzene-tethered oligonucleotides"
   Asanuma, H.; Matsunaga, D.; Liu, M.; Liang, X.; Jhao, J.; Komiyama, M.
   Nucleic Acids Res. Suppl., 2003, 3, 117-118.

解説論文

1. "DNAの光機能化"
   浅沼浩之
   高分子、2003, 52(3), 139.
2. "遺伝子発現の人工的制御"
   浅沼浩之
   バイオマテリアル-生体材料-, 2003, 21(4), 289-296.

著書

1. "Molecular imprinting - from fundamentals to applications- "
   Komiyama, M.; Takeuchi, T.; Mukawa, T.; Asanuma, H.
   2003, Wiley-VCH, Germany

2002

原著論文

1. "H-Aggregation of Methyl Reds by the Hybridization of DNA-Dye conjugates"
   Asanuma, H.; Shirasuka, K.; Komiyama, M.
   Chem. Lett., 2002, 490-491.
2. "Molecular Imprinting of Cyclodextrins Leading to Synthetic Antibodies"
   Hishiya, T.; Akiyama, T.; Asanuma, H.; Komiyama, M.
   J. Inclu. Phenom. Macrocyclic Chem., 2002, 44, 365-367.
3. "Spectroscopic Anatomy of Molecular-Imprinting of Cyclodextrin. Evidence for Preferential Formation of Ordered Cyclodextrin Assemblies"
   Hishiya, T.; Asanuma, H.; Komiyama, M.
   J. Am. Chem. Soc., 2002, 124, 570-575.
4. "Photo-Regulation of Transcription Reaction by T7 RNA Polymerase by Tethering an Azobenzene in the Promoter"
   Asanuma, H.; Tamaru, D.; Yamazawa, A.; Liu, M.; Komiyama, M.
   ChemBioChem, 2002, 3, 786-789.
5. "Photo-Regulation of DNA-Triplex Formation by Azobenzene"
   Liang, X.; Asanuma, H.; Komiyama, M.
   J. Am. Chem. Soc., 2002, 124, 1877-1883.
6. "Photo-regulation of transcription by RNA polymerase with azobenzene-tethered promoter"
   Asanuma, H.; Liu, M.; Tamaru, D.; Liang, X.; Komiyama, M.
   Nucleic Acids Res. Suppl., 2002, 2, 75-76.

解説論文

1. "分子の型を取る"
   菱谷隆行、浅沼浩之
   化学と教育, 2002, 50(1), 28-29

2001

原著論文

1. "Molecularly imprinted cyclodextrin on silica gel support for the stationary phase of high performance liquid chromatography"
   Akiyama, T.; Hishiya, T.; Asanuma, H.; Komiyama, M.
   J. Inclu. Phenom. Macrocyclic Chem., 2001, 41, 149-153.
2. "Molecular imprinting of cyclodextrin in homogeneous solutions"
   Hishiya, T.; Akiyama, T.; Asanuma, H.; Komiyama, M.
   Biological Journal of Armenia, 2001, 65-69
3. "Molecular Imprinting of Cyclodextrin in Water for the Recognition of Nanometer-scaled Guests"
   Asanuma, H.; Akiyama, T.; Kajiya, K.; Hishiya, T.; Komiyama, M.
   Anal. Chim. Acta, 2001, 435, 25-33.
4. "Phenylazonaphthalene as a Superb Photo-Regulator for DNA-Triplex Formation"
   Liang, X.; Asanuma, H.; Komiyama, M.
   Tetrahedron Lett., 2001, 42, 6723-6725.
5. "L-Threoninol as a Chiral Linker of Azobenzene for the Effective Photo-regulation of DNA Triplex Formation"
   Takarada, T.; Tamaru, D.; Liang, X.; Asanuma, H.; Komiyama, M.
   Chem. Lett., 2001, 732-733.
6. "Enantioselective incorporation of azobenzenes into oligodeoxyribonucleotide for the effective photo-regulation of duplex formation"
   Asanuma, H.; Takarada, T.; Yoshida, T.; Liang, X.; Komiyama, M.
   Angew. Chem. Int. Ed., 2001, 40, 2671-2673.
7. "Spiropyran as a regulator of DNA hybridization with reversed switching mode to that of azobenzene"
   Asanuma, H.; Shirasuka, K.; Yoshida, T.; Takarada, T.; Liang, X.; Komiyama, M.
   Chem. Lett., 2001, 108-109.
8. "Photo-Control of DNA-Duplex Formation by Use of Oligonucleotide Carrying an Azobenzene"
   Asanuma, H.; Liang, X.; Yoshida, T.; Komiyama, M.
   ChemBioChem, 2001, 2, 39-44.
9. "Regulation of aggregated structure of dye molecules by DNA hybridization"
   Asanuma, H.; Shirasuka, K.; Takarada, T.; Komiyama, M.
   Nucleic Acids Res. Suppl., 2001, 1, 193-194.
10. "Photo-regulation of RNA polymerase reaction by use of modified DNA carrying an azobenzene"
    Asanuma, H.; Tamaru, D.; Yoshida, T.; Yamazawa, A.; Mitsui, T.; Okuni, T.; Kimoto, M.; Hirao, I.; Yokoyama, S.; Komiyama, M.
    Nucleic Acids Res. Suppl., 2001, 1, 55-56.

解説論文

1. "ゲノム解析と化学"
   浅沼浩之
   化学と教育, 2001, 49(3), 136-137.

2000

原著論文

1. "Photo-Regulation of DNA Polymerase Reaction by Oligonucleotides Bearing Azobenzene"
   Yamazawa, A.; Liang, X.; Yoshida, T.; Asanuma, H.; Komiyama, M.
   Angew. Chem. Int. Ed., 2000, 39, 2356-2357.
2. "Meta-Aminoazobenzene as a Thermo-Insensitive Photo-Regulator of DNA-Duplex Formation"
   Asanuma, H.; Liang, X.; Komiyama, M.
   Tetrahedron Lett., 2000, 41, 1055-1058
3. "Modified oligo(T)s carrying an azobenzene at the 5'-ends form unexpectedly stable triple-helixes with oligo(A)/oligo(T) double-helix
   Asanuma, H.; Yoshida, T.; Liang, X.; and Komiyama, M.;
   Chem. Lett., 2000, 108-109
4. "Photo-Control of Triple-Helix Formation by Using Oligo(thymidine) Bearing Azobenzene"
   Asanuma, H.; Liang, X.; Yoshida, T.; Komiyama, M.
   Angew. Chem. Int. Ed., 2000, 39, 1316-1318.
5. "Photo-regulation of DNA/RNA duplex formation by azobenzene-tethered DNA towards antisense strategy"
   Liang, X.; Yoshida, T.; Asanuma, H.; Komiyama, M.
   Nucleic Acids Symp. Ser., 2000, 44, 277-278.

解説論文

1. "Tailor-Made Receptors by Molecular Imprinting"
   Asanuma, H.; Hishiya, T.; Komiyama, M.
   Adv. Mater., 2000, 12, 1019-1030

著書

1. "Synthesis of Hybrid Polymers Which Bind Guests in Water by Hydrogen Bond Formation"
   Asanuma, H.; Komiyama, M.
   in "Precision Polymers and Nano-Organized System" Eds. by T. Kunitake, S. Nakahama, S. Takahashi, N. Toshima
   Kodansha, p.181-184, 2000.
2. "Porous polymer complexes for gas separation"
   Asanuma, H.; Toshima, N
   in "Encyclopedia of Separation Science"
   Academic Press Ltd., 3947-3954, 2000

1999

原著論文

1. "Photo-regulation of the formation and dissociation of DNA-duplex by using the cis-trans isomerization of azobenzene"
   Asanuma, H.; Ito, T.; Yoshida, T.; Liang, X.; Komiyama, M.
   Angew. Chem. Int. Ed., 1999, 38, 2393-2395.
2. "Molecular imprinting of cyclodextrin in water for the recognition of peptides"
   Asanuma, H.; Kajiya, K.; Hishiya, T.; Komiyama, M.
   Chem. Lett., 1999, 665-666.
3. "Molecularly imprinted cyclodextrins as selective receptors for steroids"
   Hishiya, T.; Shibata, M.; Kakazu, M.; Asanuma, H.; Komiyama, M.
   Macromolecules, 1999, 32, 2265-2269.
4. "Photo-Responsive Oligonucleotides Carrying Azobenzene at the 2'-Position of the Ribonucleotide"
   Asanuma, H.; Yoshida, T.; Ito, T.; Komiyama, M.
   Tetrahedron Lett., 1999, 40, 7995-7998
5. "Photo-regulated duplex- and triplex-formation of the modified DNA carrying azobenzene"
   Asanuma, H.; Liang, X.; Yoshida, T.; Ito, T.; Komiyama, M.
   Nucleic Acids Symp. Ser., 1999, 42, 135-136

1998

原著論文

1. "Photo-responsive oligonucleotides carrying azobenzene in the side chains"
   Asanuma, H.; Itoh, T.; Komiyama, M.
   Tetrahedron Lett., 1998, 39, 9015-9018.
2. "A Study on the Origin of the J-Band of 5,5'-Dichloro-3,3',9-Triethylthiacarbocyanine Single Crystal"
   Asanuma, H.; Ogawa, K.; Fukunaga, H.; Tani, T.; Tanaka, J.
   International Congress on Imaging Science, 1998,178-182.
3. "Direct evidences for the hydrogen bonding in water by polymeric receptors carrying diaminotriazine"
   Asanuma, H.; Hishiya, T.; Komiyama, M.
   Chem. Lett., 1998, 1087-1088.
4. "Precise recognition of nucleic acid bases by polymeric receptors in methanol. Predominance of hydrogen bonding over apolar interactions"
   Asanuma, H.; Hishiya, T.; Ban, T.; Gotoh, S.; Komiyama, M.
   J. Chem. Soc. Perkin Trans. 2, 1998, 1915-1918
5. "Synthesis of Molecularly Imprinted Polymer of -Cyclodextrin for the Efficient Recognition of Cholesterol"
   Asanuma, H.; Kakazu, M.; Shibata, M.; Hishiya, T.; Komiyama, M.
   Supramolecular Sci., 1998, 5, 417-421.
6. "Precise Recognition of Nucleotides and their Derivatives through Hydrogen Bonding in Water by Poly(vinyldiaminotriazine)"
   Asanuma, H.; Ban, T.; Gotoh, S.; Hishiya, T.; Komiyama, M.
   Supramolecular Sci., 1998, 5, 405-410.
7. "Efficient RNA Hydrolysis by Lanthanide(III)/Hydrogen Peroxide Combinations. -Novel Aggregates as the Catalytic Species-"
   Kamitani, J.; Sumaoka, J.; Asanuma, H.; Komiyama, M.
   J. Chem. Soc. Perkin Trans. 2, 1998, 523-527.

特許

1. 「オリゴヌクレオチドプローブ及びその利用」
   出願人：独立行政法人　名古屋大学、　日本碍子（株）
   出願番号：PCT/JP2009/061980(特願2008-285966、特願2008-172526のPCT出願)
   出願日：2009年6月30日
   発明者：浅沼浩之、梁興国、樫田啓、吉田安子、高瀬智和、丹羽孝介
2. 「光応答性DNAエンザイム」
   特願2004-55086　浅沼浩之、倉持壮、松永大次郎、小宮山真
3. 「SNPS検出用オリゴヌクレオチド」
   特許公開２００１－３４６５７９、浅沼浩之、小宮山真
4. 「光で可逆的に構造異性化する有機分子を少なくとも一分子側鎖に有する光応答性オリゴヌクレオチドにおいて、該光応答性オリゴヌクレオチドと 実質的に相補的な配列を持つオリゴヌクレオチドとの二重鎖形成あるいは三重鎖形成の融解温度を、光照射で可逆的に変化させることが可能なことを特徴とする光応答性オリゴヌクレオチド」
   ＷＯ０１／０２１６３７ (PCT出願)　小宮山真、浅沼浩之、吉田高之、
5. 「シクロデキストリンを鋳型分子の存在下で架橋し、しかる後に該鋳型分子を除去したことを特徴とする架橋シクロデキストリン高分子の合成方法」
   特開平10-195108、小宮山真、浅沼浩之、嘉数将也
6. 「ターゲット物質の鋳型構造を担持する分離剤、およびその製造方法」
   浅沼浩之、小宮山　真、申請中
7. 「核酸誘導体および尿素を親水性溶媒中で吸着除去可能な高分子材料において、該高分子材料が式（１）に示すような残基を有することを特徴とする高分子材料」
   特開平09-302034、小宮山真、浅沼浩之