創薬科学研究科併担グループ分子設計化学

Graduate School of Pharmaceutical Science

Laboratory of Molecular Design

Staffs

  • Professor: Yoshihiko Yamamoto
  • Associate Professor: Masatoshi Shibuya

Overview of Researtch

The molecular design of candidate organic compounds that are expected to function as pharmaceutical agents plays an extremely important role in pharmaceutical sciences. During the development process from a candidate compound to the final pharmaceutical agent, both rational molecular design—which envisions derivatives with enhanced desired properties and reduced adverse drug reactions—and efficient synthesis of the final product are indispensable. Our laboratory implements creative research and education in molecular design chemistry, based on synthetic organic chemistry. This field endeavors to design new physiologically active molecules as part of the drug development pipeline. In addition, we emphasize the development of rational synthetic routes to generate these target compounds.

Research Subjects

・ Transition-metal catalysts for rapid construction of complex molecules
・ Designer organocatalysts for efficient and selective organic transformations
・ Streamlined synthetic processes for pharmaceuticals
・ Design and synthesis of novel biologically active molecules