メンバー紹介

名前: 神谷由紀子 (かみや ゆきこ)
生年月日: 1981年01月30日
メールアドレス: yukikok(at)chembio.nagoya-u.ac.jp
(アドレスご利用の際は(at)を@に変えてください)

プロフィール

1999.4 名古屋市立大学薬学部製薬学科入学
2003.3 名古屋市立大学薬学部製薬学科卒業
2003.4 名古屋市立大学大学院薬学研究科創薬生命科学専攻 修士課程入学
2005.3 名古屋市立大学大学院薬学研究科創薬生命科学専攻 修士課程修了
2005.4 名古屋市立大学大学院薬学研究科創薬生命科学専攻 博士課程入学
2006.4 日本学術振興会特別研究員(DC2)
2008.3 名古屋市立大学大学院薬学研究科創薬生命科学専攻 博士課程修了

職歴

2008.4.1 自然科学研究機構 分子科学研究所/岡崎統合バイオサイエンスセンター
IMSフェロー
2009.4.1 自然科学研究機構 分子科学研究所/岡崎統合バイオサイエンスセンター
特任助教
2012.1.1 名古屋大学大学院工学研究科 助教
2013.4.1 名古屋大学エコトピア科学研究所 講師
2015.10.1 名古屋大学未来材料・システム研究所(改組による) 講師
2016.4.1 名古屋大学大学院工学研究科 准教授

研究題目

機能性核酸を用いたRNAi機構の分子基盤の解明

主な業績

原著論文

  1. "Development of pre-miRNAs modification with FRET dye pair for intracellular visualization of processing intermediates generated in cells"
    Kamiya, Y.; Kamimoto, H.; Zhu, H. ; Asanuma, H.
    Sensors, 2021, 21, 1785. doi.org/10.3390/s21051785
  2. "Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-aTNA/RNA and SNA/RNA"
    Kamiya, Y.; Satoh, T.; Kodama, A.; Suzuki, T.; Murayama, K.; Kashida, H.; Uchiyama, S.; Kato, K.; Asanuma, H.
    Commun. Chem., 2020, 3, 156. DOI: 10.1038/s42004-020-00400-2
  3. "Investigation of strand selective interaction of SNA-modified siRNA with AGO2-MID"
    Kamiya, Y.; Takeyama, Y.; Mizuno, T.; Sato, F.; Asanuma, H.
    Int. J. Mol. Sci., 2020, 21, 5218. DOI: 10.3390/ijms21155218
  4. "Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor"
    Yagi, H.; Yagi-Utsumi, M.; Honda, R.; Ohta, Y.; Saito, T.; Nishio, M.; Ninagawa, S.; Suzuki, K.; Anzai, T.; Kamiya, Y.; Aoki, K.; Nakanishi, M.; Satoh, T.; Kato, K.
    Nat. Commun., 2020, 11, 1368. DOI:10.1038/s41467-020-15192-1
  5. "Crystallographic snapshots of the EF-hand protein MCFD2 complexed with the intracellular lectin ERGIC-53 involved in glycoprotein transport"
    Satoh, T.; Nishio, M.; Suzuki, K.; Yagi-Utsumi, M.; Kamiya, Y.; Mizushima, T.; Kato, K.
    Acta Crystallogr. F, 2020, 76, 216-221. DOI:10.1107/S2053230X20005452
  6. "A triplex-forming linear probe for sequence-specific detection of duplex DNA with high sensitivity and affinity"
    Chen, Y.; Murayama, K.; Kashida, H.; Kamiya, Y.; Asanuma, H.
    Chem. Commun., 2020, 56, 5358-5361. DOI: 10.1039/D0CC01865A
    Selected as a "Back cover"
  7. "SNA/RNA hybridization promoted with 2,6-diaminopurine and 2-thiouracil, which suppress self-hybridization of SNA"
    Kamiya, Y.; Sato, F.; Murayama, K.; Kodama, A.; Uchiyama, S.; Asanuma, H.
    Chem. Asian J., 2020, 15, 1266-1271. DOI: 10.1002/asia.201901728
    Selected as a "Cover Picture"
  8. "Bifacial nucleobases for hexaplex formation in aqueous solution"
    Kashida, H.; Hattori, Y.; Tazoe, K.; Inoue, T.; Nishikawa, K.; Ishii, K.; Uchiyama, S.; Yamashita, H.; Abe, M.; Kamiya, Y.; Asanuma, H.
    J. Am. Chem. Soc., 2018, 140, 8456-8462.
    Selected as a "Supplementary Journal Cover"
  9. "Development of visible light-responsive RNA scissors based on the 10-23 DNAzyme"
    Kamiya, Y.; Arimura, Y.; Ooi, H.; Kato, K.; Liang, X.G.; Asanuma, H.
    ChemBioChem, 2018, 19, 1305-1311. DOI: 10.1002/cbic.201800020
  10. "DNA microcapsule for photo-triggered drug release system"
    Kamiya, Y.; Yamada, Y.; Muro, T.; Matsuura, K.; Asanuma, H.
    ChemMedChem, 2017, 12, 2016-2021. DOI: 10.1002/cmdc.201700512
    Selected as a "Front Cover"
  11. "Introduction of 2,6-diaminopurines into serinol nucleic acid (SNA) improves anti-miRNA performance"
    Kamiya, Y.; Donoshita, Y.; Kamimoto, H.; Murayama, K.; Ariyoshi, J.; Asanuma, H.
    ChemBioChem, 2017, 18, 1917-1922
  12. "Dynamics of Inter-DNA Chain Interaction of Photoresponsive DNA"
    Nakasone, Y.; Ooi, H.; Kamiya, Y.; Asanuma, H.; Terazima, M.
    J. Am. Chem. Soc., 2016, 138, 9001-9004
  13. "Strand-invading linear probe combined with unmodified PNA"
    Aasanuma, H.; Niwa, R.; Akahane, M.; Murayama, K.; Kashida, H.; Kamiya, Y.
    Bioorg. Med. Chem., 2016, 24, 4129-4137. DOI:10.1016/j.bmc.2016.06.055
  14. "Isotope effect on the circular dichroism spectrum of methyl α-D-glucopyranoside in aqueous solution"
    Kanematsu, Y.; Kamiya, Y.; Matsuo, K.; Gekko, K.; Kato, K.; Tachikawa, M.
    Scientific Reports, 2015, 5, 17900, DOI:10.1038/srep17900
  15. "Terminus-free siRNA prepared by photo-crosslinking activated via slicing by Ago2"
    Kamiya, Y.; Iishiba, K.; Doi. T.; Tsuda, K.; Kashida, H.; Asanuma, H.
    Biomater. Sci., 2015, 3, 1534-1538
    Selected as a "Back cover"
  16. "Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway"
    Ninagawa, S.; Okada, T.; Sumitomo, Y.; Horimoto, S.; Sugimoto, T.; Ishikawa, T.; Takeda, S.; Yamamoto, T.; Suzuki, T.; Kamiya, Y.; Kato, K.; Mori, K.
    J. Cell Biol., 2015, 211, 775-784
  17. "Redox-coupled structural changes of the catalytic a' domain of protein disulfide isomerase"
    Inagaki, K.; Satoh, T.; Yagi-Utsumi, M.; Gulluche, A.C.; Anzai, T.; Uekusa, Y.; Kamiya, Y.; Kato, K.
    FEBS Lett., 2015, 589, 2690-2694
  18. "Ultra-Sensitive Molecular Beacon Designed with Totally Serinol Nucleic Acid (SNA) for Monitoring mRNA in Cell"
    Murayama, K.; Kamiya, Y.; Kashida, H.; Asanuma, H.
    ChemBioChem, 2015, 16, 1298-1301, DOI: 10.1002/cbic.201500167
  19. "Molecular design of Cy3 derivative for highly sensitive in-stem molecular beacon and its application to the wash-free FISH"
    Kashida, H.; Osawa, T.; Morimoto, K.; Kamiya, Y.; Asanuma, H.
    Bioorg. Med. Chem., 2015, 23, 1758-1762
  20. "Highly sensitive and robust linear probe for detection of mRNA in cells"
    Asanuma, H.; Akahane, M.; Niwa, R.; Kashida, H.; Kamiya, Y.
    Angew. Chem. Int. Ed., 2015, 54, 4315-4319
  21. "Synthetic gene involving azobenzene-tethered T7 promoter for the photocontrol of gene expression by visible light."
    Kamiya, Y.; Takagi, T.; Ooi, H.; Ito, H.; Liang, X.G.; Asanuma, H.
    ACS Synth. Biol., 2015, 4, 365-370.
  22. "Enhancement of stability and activity of siRNA by terminal substitution with Serinol Nucleic Acid (SNA)."
    Kamiya, Y.; Takai, J.; Ito, H.; Murayama, K.; Kashida, H.;?Asanuma, H.
    ChemBioChem, 2014, 15, 2549-2555.
    Selected as a "Back Cover"
  23. "EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step."
    Ninagawa, S.; Okada, T.; Sumitomo, Y.; Kamiya, Y.; Kato, K.; Horimoto, S.; Ishikawa, T.; Takeda, S.; Sakuma, T.; Yamamoto, T.; Mori, K.
    J. Cell Biol., 2014, 206, 347-356.
  24. "Selective labeling of mature RISC using siRNA carrying fluorophore-quencher pair."
    Kamiya, Y.; Ito, A.; Ito, H.; Urushihara, M.; Takai, J.; Fujii, T.; Liang, X.G.; Kashida, H.; Asanuma, H.
    Chem. Sci., 2013, 4, 4016-4021.
  25. "Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases"
    Araki,K.; Iemura, S.; Kamiya, Y.; Ron, D.; Kato, K.; Natsume, T.; and Nagata, K.
    J. Cell Biol., 2013, 202, 861-874.
  26. "The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein." Horimoto, S.; Ninagawa, S.; Okada, T,; Koba, H.; Sugimoto, T.; Kamiya, Y.; Kato, K.; Takeda, S.; and Mori, K.
    J. Biol. Chem., 2013, 288, 31517-27.
  27. "An archaeal homolog of proteasome assembly factor functions as a proteasome activator"
    Kumoi, K.; Satoh, T.; Murata, K.; Hiromoto, T.; Mizushima, T.; Kamiya, Y.; Noda, M.; Uchiyama, S.; Yagi, H.; Kato, K.
    PLoS ONE, 2013, 8, e60294.
  28. "Terminal Spin Labeling of a High-mannose-type Oligosaccharide for Quantitative NMR Analysis of Its Dynamic Conformation"
    Yamaguchi, T.; Kamiya, Y.; Choo, Y.M.; Yamamoto, S.; Kato, K.
    Chem. Lett., 2013, 42, 544-546.
  29. "Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant"
    Fujimori, T.; Kamiya, Y.; Nagata, K.; Kato, K.; Hosokawa, N.
    FEBS J., 2013, 280, 1563-1575.
  30. "Application of metabolic 13C labeling in conjunction with high-field NMR spectroscopy for comparative conformational analysis of high mannose-type oligosaccharides"
    Kamiya, Y.; Yanagi, K.; Kitajima, T.; Yamaguchi, T.; Chiba, Y.; Kato, K.
    Biomolecules, 2013, 3, 108-123.
  31. "N-Glycosylation Profiles of Chicken Immunoglobulin Y Glycoproteins Expressed by Different Production Vehicles"
    Kondo, S.; Yagi, H.; Kamiya, Y.; Ito, A.; Kuhara, M.; Kudoh, A.; Takahashi, N.; Kato, K.
    Journal of Glycomics and Lipidomics, 2012, S5. 002.
  32. "NMR characterization of the interaction between the PUB domain of peptide:N-glycanase and ubiquitin-like domain of HR23"
    Kamiya, Y.; Uekusa, Y.; Sumiyoshi, A.; Sasakawa, H.; Hirao, T.; Suzuki, T.; Kato, K.
    FEBS Lett., 2012, 586, 1141-1146.
  33. "Overexpression of a homogeneous oligosaccharide with 13C labeling by genetically engineered yeast strain"
    Kamiya, Y.; Yamamoto, S.; Chiba, Y.; Jigami, Y.; Kato, K.
    J. Biomol. NMR, 2011, 50, 397-401.
  34. "EDEM1 accelerates the trimming of α1,2-linked mannose on the C branch of N-glycans"
    Hosokawa, N.; Tremblay, L.O.; Sleno, B.; Kamiya, Y.; Wada, I.; Nagata, K.; Kato, K.; Herscovics, A.
    Glycobiology, 2010, 20, 567-575.
  35. "Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency."
    Nishio, M.; Kamiya, Y.; Mizushima, T.; Wakatsuki, S.; Sasakawa, H.; Yamamoto, K.; Uchiyama, S.; Noda, M.; McKay, A.R.; Fukui, K.; Hauri, H.-P.; Kato, K.
    Proc. Natl. Acad. Sci. USA, 2010, 107, 4034-4039.
  36. "Redox-dependent domain rearrangement of protein disulfide isomerase coupled with exposure of its substrate-binding hydrophobic surface"
    Serve, O.*; Kamiya, Y.*; Maeno, A.*; Nakano, M.*; Murakami, C.; Sasakawa, H.; Yamaguchi, Y.; Harada, T.; Kurimoto, E.; Yagi-Utsumi, M.; Iguchi, T.; Inaba, K.; Kikuchi, J.; Asami, O.; Kajino, T.; Oka, T.; Nakasako, M.; Kato, K.(*These authors contributed equally to this work)
    J. Mol. Biol., 2010, 396, 361-374.
  37. "Sugar-binding activity of the MRH domain in ER α-glucosidase II β subunit is important for efficient glucose trimming."
    Dan, H.; Kamiya, Y.; Totani, K.; Kamiya, D.; Kawasaki, N.; Yamaguchi, D.; Matsuo, I.; Matsumoto, N.; Ito, Y.; Kato, K.; Yamamoto, K.
    Glycobiology, 2009, 19, 1127-1135.
  38. "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans."
    Hosokawa, N.*; Kamiya, Y.*; Kamiya, D.; Kato, K. and Nagata, K. (*Both authors contributed equally to this work)
    J. Biol. Chem., 2009, 284, 17061-17068.
  39. "Defining the glycan destruction signal for endoplasmic reticulum-associated degradation."
    Quan, E.M.; Kamiya, Y.; Kamiya, D.; Denic, V.; Weibezahn, J.; Kato, K.; Weissman, J.S.
    Mol. Cell. 2008, 32, 870-877.
  40. "Deletion of three residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and VIII deficiency."
    Nyfeler, B.; Kamiya, Y.; Boehlen, F.; Yamamoto, K.; Kato, K.; Moerloose, P. de.; Hauri, H. -P.; Neerman-Arbez, M.
    Blood, 2008, 111, 1299-1301.
  41. "Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL and VIP36."
    Kamiya, Y.; Kamiya, D.; Yamamoto, K.; Nyfeler, B.; Hauri, H. -P.; Kato, K.
    J. Biol. Chem., 2008, 283, 1857-1861.
  42. "Fbs1 protects the malfolded glycoproteins from the attack of peptide:N-glycanase."
    Yamaguchi, Y.; Hirao, T.; Sakata, E.; Kamiya, Y.; Kurimoto, E.; Yoshida, Y.; Suzuki, T.; Tanaka, K.; Kato, K.
    Biochem. Biophys. Res. Commun., 2007, 362, 712-716.
  43. "Sugar-binding properties of VIP36, an intracellular animal lectin operating as a cargo receptor."
    Kamiya, Y.; Yamaguchi, Y.; Takahashi, N.; Arata, Y.; Kasai, K.; Ihara, Y.; Matsuo, I.; Ito, Y.; Yamamoto, K.; Kato, K.
    J. Biol. Chem., 2005, 280, 37178-37182.

総説・解説論文

  1. "Xeno nucleic acids (XNAs) having non-ribose scaffolds with unique supramolecular properties"
    Asanuma, H.; Kamiya, Y.; Kashida, H.; Murayama, K.
    Chem. Commun., 2022, 28, 3993. DOI: 10.1039/d1cc05868a
    Selected as a "Front cover"
  2. "光駆動型DNAナノマシン"
    浅沼浩之, 村山恵司, 神谷由紀子, 樫田 啓
    高分子, 2021, 70, 550-552.
  3. "The DNA duplex as an aqueous one-dimensional soft crystal scaffold for photochemistry."
    Asanuma, H.; Murayama, K.; Kamiya, Y.; Kashida, H.
    Bull. Chem. Soc. Jpn., 2018, 91, 1739-1748.
  4. "Design of photo-functional oligonucleotide by "copolymerization" of natural nucleobases with base-surrogate prepared from acyclic scaffold."
    Asanuma, H.; Murayama, K.; Kamiya, Y.; Kashida, H.
    Polymer J., 2017, 49, 279-289
  5. "Pre-organized guide RNA in Cas9 complex is ready for selection of the target double-stranded DNA"
    Kamiya, Y.; Asanuma, H.
    ChemBioChem, 2015, 16, 2273-2275, DOI: 10.1002/cbic.201500424
  6. "Reversible photo-switching of DNA fuction with azobenzene-tethered DNA"
    Kamiya, Y.; Asanuma, H.
    The Glen Report, 2015, 27, 1-3
  7. "Conformational dynamics of oligosaccharides characterized by paramagnetism-assisted NMR spectroscopy in conjunction with molecular dynamics simulation"
    Zhang, Y.; Yamaguchi, T.; Yagi-Utsumi, M.; Kamiya, Y.; Sakae, Y.; Okamoto, Y.; Kato, K.
    Advances in Experimental Medicine and Biology (A.Chakrabarti and A.Surolia ed.), Springer (Switzerland), 2015, 842, 389-401
  8. "De Novo Design of Functional Oligonucleotides with Acyclic Scaffolds"
    Asanuma, H.; Kashida, H.; Kamiya, Y.
    Chem. Rec. 2014, 14, 1055-1069.
  9. "Light-driven DNA nanomachine with a photoresponsive molecular engine."
    Kamiya, Y.; Asanuma, H.
    Accounts of Chemical Research, 2014, 47, 1663-1672.
  10. "Recent advances in glycoprotein production for structural biology:toward tailored design of glycoforms"
    Kamiya, Y.; Satoh T.; Kato, K.
    Current Opinion in Structural Biology, 2014, 26, 44-53.
  11. "Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells"
    Kamiya, Y.; Satoh, T.; Kato, K.
    Biochimica et Biophysica Acta - General Subjects, 2012, S5, 1327-1337.
  12. "Structural and molecular basis of carbohydrate-protein interaction systems as potential therapeutic targets."
    Kamiya, Y.; Yagi-Utsumi, M.; Yagi, H.; Kato, K.
    Curr. Pharm. Des., 2011, 17, 1672-1684.
  13. "Redox-dependent chaperoning, following PDI footsteps."
    Serve, O.; Kamiya, Y.; Kato, K.
    Protein Folding, (E.C.Walters ed.), NOVA Science Publishers (New York), 2011, 489-500.
  14. "Mannose 6-phosphate receptor homology domain-containing lectins in mammalian endoplasmic reticulum-associated degradation"
    Hosokawa, N.; Kato, K.; Kamiya, Y.
    Methods Enzymol., 2010, 480, 181-197.
  15. "The role of MRH domain-containing lectins in ERAD"
    Hosokawa, N.; Kamiya, Y.; Kato, K.
    Glycobiology, 2010, 20, 651-660.
  16. "糖鎖によるタンパク質社会の秩序維持"
    神谷由紀子、 加藤晃一
    化学工業, 2010, 61, 23-31.
  17. "Sophisticated modes of sugar recognition by intracellular lectins involved in quality control of glycoproteins"
    Kamiya, Y.; Kamiya, D.; Urade, R.; Suzuki, T.; Kato, K.
    Glycobiology Research Trends, (G.Powell and O.McCabe ed.), NOVA Science Publishers (New York), 2009, 27-40.
  18. "糖鎖認識を介した糖タンパク質の細胞内運命の決定機構"
    神谷由紀子、加藤晃一
    生物物理, 2009, 49, 62-69.
  19. "細胞内レクチンによる糖蛋白質の輸送と品質管理の構造基盤"
    神谷由紀子、加藤晃一
    蛋白質 核酸 酵素, 2008, 53, 1662-1669.
  20. "920 MHz ultra-high field NMR approaches to structural glycobiology."
    Kato, K.; Sasakawa, H.; Kamiya, Y.; Utsumi, M.; Nakano, M.; Takahashi, N.; Yamaguchi, Y.
    Biochimica et Biophysica Acta - General Subjects, 2008, 1780, 619-625.
  21. "Structural views of glycoprotein-fate determination in cells."
    Kato, K.; Kamiya, Y.
    Glycobiology, 2007, 17, 1031-1044.
  22. "Sugar recognition by intracellular lectins that determine the fates of glycoproteins."
    Kamiya, Y.; Kato, K.
    Trends Glycosci. Glycotech, 2006, 18, 231-244.

著書

  1. 「光応答性DNAの搭載によるナノマシンとナノ構造体の光制御」
    浅沼浩之, 神谷由紀子
    "進化を続ける核酸化学" 日本化学会編, 化学同人
  2. "ナノマテリアルとしての光応答性DNA"
    浅沼浩之、神谷由紀子
    "刺激応答性高分子ハンドブック"、監修:宮田 隆志、p.581-587、エヌ・ティー・エス(2018)
  3. "非環状骨格型人工核酸:aTNA, SNA"
    神谷由紀子、村山恵司、樫田 啓、浅沼浩之
    "核酸医薬の創製と応用展開"、監修:和田 猛、 p79-86、シーエムシー出版(2016)
  4. "核酸医薬を目指した機能性siRNA"
    神谷由紀子、浅沼浩之
    最先端メディカルエンジニアリング 第2版, 2014, 94-98
  5. "ナノ環境に優しい光応答性DNAの設計"
    神谷由紀子、浅沼浩之
    "太陽エネルギー社会を築く材料テクノロジー(I) -材料・デバイス編-"
    名古屋大学大学院工学研究科 材料バックキャストテクノロジー研究センター 編
    コロナ社, 2013, 192-210

新聞記事

  1. 先端人:朝日新聞(名古屋本社版 2020/1/19)30面(東海経済)
    神谷由紀子

受賞歴

  • 2004年 日米合同糖質会議 ポスター賞
  • 2008年 特定領域研究「タンパク質の社会」平成20年度全体班会議 ポスター優秀賞
  • 2010年 糖質科学名古屋拠点 若手研究者奨励賞(2009年度)
  • 2013年 第77回日本生化学会中部支部例会 日本生化学会中部支部奨励賞
  • 2013年 第23回バイオ・高分子シンポジウム 若手研究者奨励講演賞
  • 2014年 日本化学会第94春季年会 優秀講演賞
  • 2019年 令和元年度「女性研究者トップリーダー顕彰」

趣味

煎茶道、旅