Bioinspired Conjugates for Chemical Biology
Research Introduction

News & Topics

2024/10/22
"In Vivo Efficacy and Safety of Systemically Administered Serinol Nucleic Acid-Modified Antisense Oligonucleotides in Mouse Kidney" (collaborative work with Prof. Ishimoto and Prof. Maruyama) was accepted for publication in Mol. Ther. Nucleic Acids
2024/8/24
"Localized Control of the Swarming of Kinesin-Driven Microtubules Using Light" (collaborative work with Prof. Kakugo) was accepted for publication in ACS Omega
2024/6/7
"Kinetics of Strand Displacement Reaction with Acyclic Artificial Nucleic Acids" by Dr. Makino and Dr. Kashida et al. was accepted for publication in Angew. Chem. Int. Ed.
2024/5/27
"A Light-powered single-stranded DNA molecular motor with colour-selective single-step control" (collaborative work with Prof. Zhisong Wang) was accepted for publication in Angew. Chem. Int. Ed.
2024/2/20
"Photosensitization of TiO2 Electrodes Immobilized with Chiral Plasmonic Au Nanocolloids by Circularly Polarized Light Irradiation" (collaborative work with Prof. Torimoto) was accepted for publication in J. Chem. Phys.
2024/1/27
"Site-selective photo-crosslinking of stilbene pairs in a DNA duplex mediated by ruthenium photocatalyst" by Dr. Kashida et al. was accepted for publication in Angew. Chem.
2024/1/20
"DNA reaction system that acquires classical conditioning" (collaborative work with Prof. Nakakuki) was accepted for publication in ACS Synth. Biol.
2023/12/21
"Unexpectedly stable homopurine parallel triplex of SNA:RNA*SNA and L-aTNA:RNA*L-aTNA" by Mr. Lao, Dr. Kamiya et al. was accepted for publication in Chem. Commun.
2023/9/22
"Illuminating miRNA inhibition: Visualizing the interaction between anti-miRNA oligonucleotide and target miRNA using FRET" by Ms. Zhu, Dr. Kamiya et al. was accepted for publication in ACS Chem. Biol.
2023/8/28
"Highly Functional Acyclic Xeno Nucleic Acids" (Award accounts) by Dr. Murayama et al. was accepted for publication in Bull. Chem. Soc. Jpn.
2023/7/7
"Rapid Chemical Ligation of DNA and of Acyclic Threoninol Nucleic Acid (aTNA) for Effective Nonenzymatic Primer Extension" by Ms. Okita, Dr. Murayama et al. was accepted for publication in J. Am. Chem. Soc.
2023/2/21
"Functionalization of Acyclic Xeno Nucleic Acid with Modified Nucleobases" (Focus review) by Dr. Murayama et al. was accepted for publication in Polym. J.
2023/2/7
"Orientational control of circularly polarized luminescence from pyrene clusters using a DNA scaffold" by Dr. Kashida et al. was accepted for publication in Chem. Eur. J.
2022/12/25
"Syntheses of base-labile pseudo-complementary SNA and L-aTNA phosphoramidite monomers" by Mr. Sato, Dr. Kamiya et al. was accepted for publication in J. Org. Chem.
2022/7/8
"UV light-triggered swarming of microtubules driven by kinesin motors" (collaborative work with Prof. Kakugo) was accepted for publication in Polym. J.
2022/4/26
"Cooperative cargo transportation by a swarm of molecular machines" (collaborative work with Prof. Kakugo) was accepted for publication in Sci. Robot.
2022/3/5
"Methyl group configuration on acyclic threoninol nucleic acids (aTNAs) impacts supramolecular properties" by Dr. Murayama et al. was accepted for publication in Org. Biomol. Chem..
2022/2/26
"Orthogonal amplification circuits composed of acyclic nucleic acids enable RNA detection" by Mr. Chen, Dr. Murayama et al. was accepted for publication in J. Am. Chem. Soc..
2022/1/27
"Renewable DNA Proportional-Integral Controller with Photoresponsive Molecules" (collaborative work with Prof. Nakakuki) was accepted for publication in Micromachines.
2022/1/22
"Xeno nucleic acids (XNAs) having non-ribose scaffolds with unique supramolecular properties" was accepted for publication in Chem. Commun.
2022/1/5
"Color-Changing Fluorescent Barcode Based on Strand Displacement Reaction Enables Simple Multiplexed Labeling" by Mr. Makino, Dr. Kashida et al. was accepted for publication in J. Am. Chem. Soc.
"Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection" by Mr. Chen et al. was accepted for publication in Chem. Lett.
"Unexpected Dissociation of Photoresponsive UV-ON DNA Carrying p-tert-Butyl Azobenzene under UV Light Irradiation" (collaborative work with Dr. Kakugo et al.) was accepted for publication in Chem. Lett.
2021/9/2
"Pyrene modified serinol nucleic acid nanostructure converts chirality of threoninol nucleic acids into circularly polarized luminescence signals" by Dr. Kashida et al. was accepted for publication in Chem. Eur. J.
2021/7/17
"Perylene-Cy3 FRET System to Analyze Photoactive DNA Structures" by Mr. Kawai et al. was accepted for publication in Chem. Eur. J.
2021/5/13
"Design and Hybridization Properties of Acyclic Nucleic Acid Oligomers" (mini review) by Dr. Murayama and Prof. Dr. Asanuma was accepted for publication in ChemBioChem.
2021/3/17
"Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA" (collaborative work with Baba Lab.) was accepted for publication in Nanotechnology.
2021/3/12
"Preparation of artificial hexaplex composed of non-natural nucleic acid" by Mr. Makino, Dr. Kashida, et al. was accepted for publication in Current Protocols.
2021/2/27
"Development of pre-miRNAs modification with FRET dye pair for intracellular visualization of processing intermediates generated in cells" by Dr. Kamiya et al. was accepted for publication in Sensors
2021/2/16
The paper by Dr. Kashida et al. was selected as Outside Backcover in Chem. Sci.
2021/2/10
The paper by Dr. Murayama et al. was selected as a Featured article in Nat. Commun..
2021/1/13
"Light-regulated liquid-liquid phase separation for spatiotemporal protein recruitment and cell aggregation" (collaborative work with Prof. Maruyama and Dr. Shimada) was accepted for publication in ACS Appl. Mater. Interfaces.
2021/1/5
"Non-enzymatic polymerase-like template-directed synthesis of acyclic L-threoninol nucleic acid" by Dr. Murayama et al. was accepted for publication in Nat. Commun.
2020/12/23
"Helical amplification system composed of artificial nucleic acids" by Dr. Kashida et al. was accepted for publication in Chem. Sci.
2020/11/7
"Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-aTNA/RNA and SNA/RNA" by Dr. Kamiya et al. was accepted for publication in Commun. Chem.
2020/9/6
"Dual crosslinking photo-switches for orthogonal photo-control of hybridization between serinol nucleic acid and RNA" by Mr. Yamano and Dr. Murayama, et al. was accepted for publication in Chem. Eur. J.
2020/9/4
"Quantitative analyses of pyrene homo FRET using DNA scaffolds" by Dr. Kashida et al. was accepted for publication in ChemPhotoChem
2020/7/21
"Investigation of strand selective interaction of SNA-modified siRNA with AGO2-MID" by Dr. Kamiya et al. was accepted for publication in Int. J. Mol. Sci.
2020/6/24
"Photo-regulated trajectories of gliding microtubules conjugated with DNA" (collaborative work with Prof. Kakugo) was accepted for publication in Chem. Commun.
2020/5/19
The paper by Mr. Chen et al. was selected as a Back cover in Chem. Commun.
2020/4/17
"A triplex-forming linear probe for sequence-specific detection of duplex DNA with high sensitivity and affinity" by Mr. Chen et al. was accepted for publication in Chem. Commun.
2020/4/8
"Efficient Light-harvesting Antenna Results from Densely Organizing Dyes into a DNA Junction via D-threoninol" by Dr. Kashida et al. was accepted for publication in Angew. Chem. Int. Ed.
2020/4/2
The paper by Dr. Kamiya et al. was selected as a Cover Picture in Chem. Asian J.
2020/2/4
"SNA/RNA hybridization promoted with 2,6-diaminopurine and 2-thiouracil, which suppress self-hybridization of SNA" by Dr. Kamiya et al. was accepted for publication in Chem. Asian J..
2020/1/21
The paper by Dr. Murayama et al. was selected as a Cover Feature in ChemBioChem
2019/9/24
"Serinol Nucleic Acid with a Fluorescent Uracil Analog serves as a Quencher-free Linear Probe" by Dr. Murayama et al. was accepted for publication in ChemBioChem.
2019/7/18
The paper by Dr. Kashida et al. was selected as a Front Cover in Org. Biomol. Chem.
2019/6/19
The paper by Prof. Dr. Asanuma et al. was selected as a Cover Feature in ChemPhotoChem
The paper by Dr. Murayama et al. was selected as a Supplementary Cover in J. Am. Chem. Soc.
2019/5/21
"8-Pyrenylvinyl Adenine Controls Reversible Duplex Formation between Serinol Nucleic Acid and RNA by [2+2] Photocycloaddition" by Dr. Murayama and Mr. Yamano, et al. was accepted for publication in J. Am. Chem. Soc..
2019/5/15
"Selective binding of nucleosides to gapped DNA duplex revealed by orientation and distance dependence of FRET" by Dr. Kashidaet al. was accepted for publication in Org. Biomol. Chem..
2019/5/7
"cis-on/trans-off of DNA hybridization with alkylthio-azobenzene on L-threoninol responding to visible light" by Prof. Asanumaet al. was accepted for publication in ChemPhotoChem.
2019/3/22
"Orthogonally Photocontrolled Non-Autonomous DNA Walker" (collaborative work with Prof. Famulok) was accepted for publication in Angewandte Chemie.
"The Use of Serinol Nucleic Acids as Ultrasensitive Molecular Beacons" by Dr. Murayama et al. was accepted for publication in Methods in Molecular Biology.
2019/2/28
"Isothermal double-cycle catalytic system using DNAzyme and RNase H for highly selective one-pot detection of oligonucleotides" (collaborative work with Prof. Liang) by Dr. An et al. was accepted for publication in analyst.
2019/1/18
"n-stem molecular beacon targeted to a 5’-region of tRNA inclusive of the D arm that detects mature tRNA with high sensitivity" (collaborative work with Prof. Watanabe and Prof. Ohtsuki) by Prof. Kashida et al. was accepted for publication in PLOS ONE
2018/12/18
"Photo-regulatable DNA isothermal amplification by template-mediated ligation" (collaborative work with Prof. Maruyama) by Mr. Cheng et al. was accepted for publication in Chem. Commun.
2018/11/7
"Quantitative evaluation of energy migration between identical chromophores enabled by breaking symmetry" by Dr. Kashida et al. was accepted for publication in Communications Chemistry
2018/9/20
Award Accounts by Asanuma et al. has been accepted for publication in Bull. Chem. Soc. Jpn.
2018/6/14
Dr. Kashida's paper was selected as a Supplementary Journal Cover in J. Am. Chem. Soc.
2018/6/11
"Bifacial nucleobases for hexaplex formation in aqueous solution" by Dr. Kashida et al. was accepted for publication in J. Am. Chem. Soc.
2018/4/21
"Development of visible light-responsive RNA scissors based on the 10-23 DNAzyme" by Dr. Kamiya et al. was accepted for publication in ChemBioChem
2018/1/5
Dr. Kamiya's paper was selected as a Front Cover in ChemMedChem
2017/12/13
"DNA-assisted swarm control in a biomolecular motor system" (collaborative work with Prof. Kakugo and Prof. Kuzuya) was accepted for publication in Nature Communications.
2017/9/15
"DNA microcapsule for photo-triggered drug release system" (collaborative work with Prof. Matsuura) by Dr. Kamiya was accepted for publication in ChemMedChem.
2017/8/3
Mr. Cheng's paper was selected as a Front Cover in ChemBioChem
2017/7/29
"Introduction of 2,6-diaminopurines into serinol nucleic acid (SNA) improves anti-miRNA performance" by Dr. Kamiya et al. was accepted for publication in ChemBioChem
2017/6/29
Our collaborative work with Prof. Veedu was accepted for publication in ACS Advances.
2017/6/20
"D-aTNA circuit orthogonal to DNA can be operated by RNA input via SNA" by Dr. Murayama et al. was accepted for publication in ChemistrySelect
2017/6/6
"Chaperone polymer-assisted, photo-driven DNA strand displacement" (collaborative work with Prof. Maruyama) by Mr. Cheng was accepted for publication in ChemBioChem.
2017/3/13
"Orientation-dependent FRET system reveals differences in structures and flexibilities of nicked and gapped DNA duplexes" by Dr. Kashida et al. was accepted for publication in Nucleic Acids Res.
2017/2/8
Review paper by Kashida et al. has been accepted for publication in Japanese Journal of Polymer Science and Technology.
2016/12/3
Review paper by Kashida et al. has been accepted for publication in Bull. Chem. Soc. Jpn..
2016/11/15
Review paper by Asanuma et al. has been accepted for publication in Polymer J..
2016/10/24
"Effect of Methyl Group on Acyclic Serinol Scaffold for Tethering Dyes on DNA Duplex stability" by Dr. Murayama et al. was accepted for publication in ChemBioChem.
2016/6/29
"Strand-invading linear probe combined with unmodified PNA" by Ms. Niwa, Ms. Akahane, et al., was just accepted for publication in Bioorg. Med. Chem..
2016/5/6
"Visible Light-Triggered Crosslinking of DNA Duplex by Reversible [2+2] Photocycloaddition of Styrylpyrene" by Dr. Doi et al. was accepted for publication in Chem. Eur. J..
2016/4/5
"A stem-less probe using spontaneous pairing between Cy3 and quencher for RNA detection" by Dr. Kashida et al. was accepted for publication in Sci. Technol. Adv. Mater..
2016/2/16
Dr.Kashida's review was accepted for publication in Polymer J..
2015/11/10
Dr.Kamiya's article was selected as a Back cover in Issue 12 of Biomaterials Science
2015/10/23
"Terminus-free siRNA prepared by photo-crosslinking activated via slicing by Ago2." by Dr.Yukiko Kamiya et al. was just accepted for publication in Biomaterials Science.
2015/9/28
Mr. Doi's article was selected as a Frontispiece in Chem. Eur. J..
2015/9/14
Our collaborative work with Prof. Heckel was accepted for publication in Chem. Eur. J..
2015/8/20
Highlight atricle "Pre-organized guide RNA in Cas9 complex is ready for selection of the target double-stranded DNA" by Dr. Kamiya et al. was accepted for publication in ChemBioChem.
2015/7/30
"Hetero-Selective DNA-like Duplex Stabilized by Donor-Acceptor Interaction" by Mr. Doi et al. was just accepted for publication in Chem. Eur. J..
2015/4/1
"Ultra-Sensitive Molecular Beacon Designed with Totally Serinol Nucleic Acid (SNA) for Monitoring mRNA in Cell" by Dr. Murayama et al. was accepted for publication in ChemBioChem.
2015/4/1
Our paper entitled "Efficiency of [2+2] photodimerization of various stilbene derivatives within the DNA duplex scaffold" was selected as Front cover in Volume 13, Issue 15 of Org. Biomol. Chem..
2015/3/31
Our paper entitled "Acyclic L-Threoninol Nucleic Acid (L-aTNA) with Suitable Structural Rigidity Cross-pairs with DNA and RNA." was selected as Back cover in Volume 51, Issue 30 of Chem. Commun..
2015/2/18
"Molecular design of Cy3 derivative for highly sensitive in-stem molecular beacon and its application to the wash-free FISH" by Dr. Kashida et al. was just accepted for publication in Bioorg. Med. Chem..
2015/2/6
"Efficiency of [2+2] photodimerization of various stilbene derivatives within the DNA duplex scaffold" by Mr. Doi et al. was accepted for publication in Org. Biomol. Chem..
2015/1/15
"Highly sensitive and robust linear probe for detection of mRNA in cells" by Ms. Akahane and Ms. Niwa et al. was just accepted for publication in Angewandte Chemie.
2015/1/13
"Acyclic L-Threoninol Nucleic Acid (L-aTNA) with Suitable Structural Rigidity Cross-pairs with DNA and RNA" by Mr. Murayama et al. was accepted for publication in Chemical Communications.
2014/11/26
Our paper entitled "Enhancement of stability and activity of siRNA by terminal substitution with Serinol Nucleic Acid (SNA)." was selected as Back Cover in Issue 17 of ChemBioChem.
2014/11/19
Our collaborative work with Prof. Heckel was accepted for publication in Chem. Eur. J..
2014/8/22
"Synthetic gene involving azobenzene-tethered T7 promoter for the photocontrol of gene expression by visible light." by Dr.Yukiko Kamiya et al. was just accepted for publication in ACS Synthetic Biology.
2014/8/11
"Enhancement of stability and activity of siRNA by terminal substitution with Serinol Nucleic Acid (SNA)." by Dr. Yukiko Kamiya et al. was just accepted for publication in ChemBioChem.
2014/7/08
Our review "De Novo Design of Functional Oligonucleotides with Acyclic Scaffolds" was just accepted for pulication in The Chemical Record.
2013/10/01
Redesigned website has been launched.
2013/04/09
Publications, Members have been updated.