Publications

All papers

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005

2024

Original Paper

  1. "Kinetics of Strand Displacement Reaction with Acyclic Artificial Nucleic Acids"
    Makino, K.; Sugiyama, I.; Asanuma, H.; Kashida, H.
    Angew. Chem. Int. Ed., 2024, accepted, . DOI:
  2. "A Light-powered single-stranded DNA molecular motor with colour-selective single-step control"
    Anderson, T.; Wu, W.; Sirbu, O.; Tong, K.; Winna, S.; Liu, X. R.; Kou, B.; Murayama, K.; Asanuma, H.; Wang, Z.
    Angew. Chem. Int. Ed., 2024, accepted, DOI:
  3. "Photosensitization of TiO2 Electrodes Immobilized with Chiral Plasmonic Au Nanocolloids by Circularly Polarized Light Irradiation"
    Kameyama, T.; Isogawa, S.; Akiyoshi, K.; Kashida, H.; Asanuma, H.; Torimoto, T.
    J. Chem. Phys., 2024, 160, 094709. DOI: https://doi.org/10.1063/5.0192366
  4. "Site-selective photo-crosslinking of stilbene pairs in a DNA duplex mediated by ruthenium photocatalyst"
    Kashida, H.; Azuma, H.; Sotome, H.; Miyasaka, H.; Asanuma, H.
    Angew. Chem. Int. Ed., 2024, 63, e202319516. DOI: https://doi.org/10.1002/anie.202319516
    Selected as a "Inside back cover"
    Selected as a "Hot paper"
  5. "DNA reaction system that acquires classical conditioning"
    Nakakuki, T.; Toyonari, M.; Aso, K.; Murayama, K.; Asanuma, H.; de Greef, T.
    ACS Synth. Biol., 2024, 13, 521-529. DOI: https://doi.org/10.1021/acssynbio.3c00459
  6. "Unexpectedly stable homopurine parallel triplex of SNA:RNA*SNA and L-aTNA:RNA*L-aTNA"
    Kamiya, Y.; Lao, S.; Ariyoshi, J.; Sato, F.; Asanuma, H.
    Chem. Commun., 2024, 60, 1257-1260. DOI: doi.org/10.1039/D3CC05555H
    Selected as a "Front Cover"

2023

Original Paper

  1. "Illuminating miRNA inhibition: Visualizing the interaction between anti-miRNA oligonucleotide and target miRNA using FRET"
    Zhu, H.; Kamiya, Y.; Asanuma, H.
    ACS Chem. Biol., 2023, 18, 2281-2289. DOI: doi.org/10.1021/acschembio.3c00353
    Selected as a "Front Cover"
  2. "Rapid Chemical Ligation of DNA and Acyclic Threoninol Nucleic Acid (aTNA) for Effective Nonenzymatic Primer Extension"
    Okita, H.; Kondo, S.; Murayama, K.; Asanuma, H.
    J. Am. Chem. Soc., 2023, 145, 17872-17880. DOI: 10.1021/jacs.3c04979
    Selected as a "Supplementary Cover"
  3. "Orientational control of circularly polarized luminescence from pyrene clusters using a DNA scaffold"
    Kashida, H.; Ito, Y.; Kakuta, T.; Ogoshi, T.; Asanuma, H.
    Chem. Eur. J., 2023, e202300182. DOI: doi.org/10.1002/chem.202300182
    Selected as a "Front Cover"
  4. "Syntheses of base-labile pseudo-complementary SNA and L-aTNA phosphoramidite monomers"
    Sato, F.; Kamiya, Y.; Asanuma, H.
    J. Org. Chem., 2023, 88, 796-804. DOI: 10.1021/acs.joc.2c01911
    Selected as a "Supplementary Cover"

Review

  1. "Highly Functional Acyclic Xeno Nucleic Acids"
    Murayama, K.; Okita, H.; Asanuma, H.
    Bull. Chem. Soc. Jpn., 2023, 96, 1179-1187. DOI: doi.org/10.1246/bcsj.20230188
  2. "Functionalization of Acyclic Xenonucleic Acid with Modified Nucleobases"
    Murayama, K.; Yamano, Y.; Asanuma, H.
    Polym. J., 2023, 55, 743-752. DOI: doi.org/10.1038/s41428-023-00776-7

Books

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2022

Original Paper

  1. "DNA Concentration Regulator That can be Driven for a Long Time"
    Nakakuki, T.; Murayama, K.; Asanuma, H.
    New Gener. Comput., 2022, 40, 681-702. DOI: https://doi.org/10.1007/s00354-022-00173-3
  2. "Kinesin motors driven microtubule swarming triggered by UV light"
    Ishii, S.; Akter, M.; Murayama, K.; Kabir, A. M. R.; Asanuma, H.; Sada, K.; Kakugo, A.
    Polym. J., 2022, 54, 1501-1507. DOI: https://doi.org/10.1038/s41428-022-00693-1
  3. "Cooperative cargo transportation by a swarm of molecular machines"
    Akter, M.; Keya, J. J.; Kayano, K.; Kabir, A. M. R.; Inoue, D.; Hess, H.; Sada, K.; Kuzuya, A.; Asanuma, H.; Kakugo, A.
    Sci. Robot., 2022, 7, eabm0677. DOI: 10.1126/scirobotics.abm0677
  4. "Methyl group configuration on acyclic threoninol nucleic acids (aTNAs) impacts supramolecular properties"
    Murayama, K.; Kashida, H.; Asanuma, H.
    Org. Biomol. Chem., 2022, 20, 4115-4122. DOI: 10.1039/d2ob00266c
    Selected as a "Front Cover"
  5. "Orthogonal amplification circuits composed of acyclic nucleic acids enable RNA detection"
    Chen, Y.; Nagao, R.; Murayama, K.; Asanuma, H.
    J. Am. Chem. Soc., 2022, 144, 5887-5892. DOI: 10.1021/jacs.1c12659
    Selected as a "Supplementary Cover"
  6. "Renewable DNA proportional-integral controller with photoresponsive molecules"
    Tamba, M.; Murayama, K.; Asanuma, H.; Nakakuki, T.
    Micromachines, 2022, 13, 193. doi.org/10.3390/mi13020193
  7. "Color-Changing Fluorescent Barcode Based on Strand Displacement Reaction Enables Simple Multiplexed Labeling"
    Makino, K.; Susaki, E.; Endo, M.; Asanuma, H.; Kashida, H.
    J. Am. Chem. Soc., 2022, 144, 1572-1579. DOI: 10.1021/jacs.1c09844
  8. "Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection"
    Chen, Y.; Murayama, K.; Asanuma, H.
    Chem. Lett., 2022, 51, 330-333. DOI:10.1246/cl.210813
  9. "Unexpected Dissociation of Photoresponsive UV-ON DNA Carrying p-tert-Butyl Azobenzene under UV Light Irradiation"
    Ishii, S.; Murayama, K.; Sada, K.; Asanuma, H.; Kakugo, A.
    Chem. Lett., 2022, 51, 292-295. DOI:10.1246/cl.210788

Review

  1. "Xeno nucleic acids (XNAs) having non-ribose scaffolds with unique supramolecular properties"
    Asanuma, H.; Kamiya, Y.; Kashida, H.; Murayama, K.
    Chem. Commun., 2022, 28, 3993. DOI: 10.1039/d1cc05868a
    Selected as a "Front cover"

Books

  1. "6.5 Orthogonality of Nucleic Acids"
    Keiji Murayama, Hiroyuki Asanuma
    "Molecular Robotics An Introduction", Satoshi Murata Ed., Springer, p.230-238. (2022)

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2021

Original Paper

  1. "Pyrene modified serinol nucleic acid nanostructure converts chirality of threoninol nucleic acids into circularly polarized luminescence signals"
    Kashida, H.; Nishikawa, K.; Ito Y.; Murayama, K.; Hayashi, I.; Kakuta, T.; Ogoshi, T.; Asanuma, H.
    Chem. Eur. J., 2021, 27, 14582-14585. DOI: 10.1002/chem.202102333
    Selected as a "Cover Feature"
  2. "Perylene-Cy3 FRET System to Analyze Photoactive DNA Structures"
    Kawai, H.; Doi, T.; Ito Y.; Kameyama T.; Torimoto T.; Kashida, H.; Asanuma, H.
    Chem. Eur. J., 2021, 27, 12845-12850. DOI: 10.1002/chem.202101738
  3. "Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA"
    Takahashi, H.; Yasui, T.; Kashida, H.; Makino, K.; Shinjo, K.; Liu, Q.; Shimada, T.; Rahong, S.; Kaji, N.; Asanuma, H.; Baba, Y.
    Nanotechnology, 2021, 32, 255301. DOI: 10.1088/1361-6528/abef2c
  4. "Preparation of artificial hexaplex composed of non-natural nucleic acid"
    Makino, K.; Hattori, Y.; Kashida, H.; Asanuma, H.
    Current Protocols, 2021, 1, e106. DOI: 10.1002/cpz1.106
  5. "Development of pre-miRNAs modification with FRET dye pair for intracellular visualization of processing intermediates generated in cells"
    Kamiya, Y.; Kamimoto, H.; Zhu, H. ; Asanuma, H.
    Sensors, 2021, 21, 1785. doi.org/10.3390/s21051785
  6. "Light-regulated liquid-liquid phase separation for spatiotemporal protein recruitment and cell aggregation"
    Ikeuchi, N.; Komachi, T.; Murayama, K.; Asanuma, H.; Maruyama, A.; Shimada, N.
    ACS Appl. Mater. Interfaces, 2021, 13, 5652-5659. DOI: 10.1021/acsami.0c22314
  7. "Nonenzymatic polymerase-like template-directed synthesis of acyclic L-threoninol nucleic acid"
    Murayama, K.; Okita, H.; Kuriki, T.; Asanuma, H.
    Nat. Commun., 2021, 12, 804. DOI: 10.1038s41467-021-21128-0
    Selected as a featured article
  8. "Helical amplification system composed of artificial nucleic acids"
    Kashida, H.; Nishikawa, K.; Shi, W.; Miyagawa, T.; Yamashita, H.; Abe, M.; Asanuma, H.
    Chem. Sci., 2021, 12,1656-1660. DOI: 10.1039/d0sc05245k
    Selected as "Outside Backcover"
  9. "Dual crosslinking photo-switches for orthogonal photo-control of hybridization between serinol nucleic acid and RNA"
    Yamano, Y.; Murayama, K.; Asanuma, H.
    Chem. Eur. J., 2021, 27, 4599-4604. doi.org/10.1002/chem.202003528
    Selected as a "Cover Feature"
  10. "Quantitative Analyses of Forster Resonance Energy Transfer between Identical Pyrene Chromophores (Homo‐FRET) In DNA Scaffolds"
    Kashida, H.; Kawai, H.; Azuma, H.; Araki, Y.; Wada, T.; Asanuma, H.
    ChemPhotoChem, 2021, 5, 167-172. doi.org/10.1002/cptc.202000199

Review

  1. "Possibility of pre-RNA world with acyclic XNA before RNA"
    Asanuma, H.; Okita, H.; Murayama, K.
    Viva Origino, 2021, 49, 9. DOI: https://doi.org/10.50968/vivaorigino.49_9
  2. "Pseudo Base Pairs that Exhibit High Duplex Stability and Orthogonality through Covalent and Non-covalent Interactions"
    Kashida, H.; Asanuma, H.
    J. Synth. Org. Chem. Jpn., 2021, 79, 1013-1019.
  3. "Design and Hybridization Properties of Acyclic Xeno Nucleic Acid Oligomers"
    Murayama, K.; Asanuma, H.
    ChemBioChem, 2021, 22, 2507-2515. doi.org/10.1002/cbic.202100184
    Selected as "Cover Feature"

Presentations

  1. Pacifichem2021 (Dec. 16-21, Virtual)
    [Invited]
    "Serinol Nucleic Acid and its derivative for potential therapeutic applications"
    Hiroyuki Asanuma, Yukiko Kamiya, Fuminori Sato
    "Development of siRNA and anti-miRNA oligonucleotide modified with SNA or L-aTNA"
    Yukiko Kamiya, Fuminori Sato, Tomonari Mizuno, Hiroyuki Asanuma
    [Oral]
    "Development of light harvesting antenna using DNA with multiple fluorophores"
    Hidenori Azuma, Hiromu Kashida, Yasuyuki Araki, Takehiko Wada, Hiroyuki Asanuma
    "Development of fluorescent probes detecting RNA"
    Hiromu Kashida
    "Development of fluorescent barcode utilizing strand exchange reaction of nucleic acids"
    Koki Makino, Hiromu Kashida, Hiroyuki Asanuma
    [Poster]
    "Sensitive triplex-forming linear probe tethering perylene derivatives for duplex DNA detection with high affinity"
    Yanglingzhi Chen, Keiji Murayama, Hiroyuki Asanuma
    "Nonenzymatic pseudo-primer extension reaction for duplication and reverse transcription of acyclic L-threoninol nucleic acids"
    Hikari Okita, Keiji Murayama, Hiroyuki Asanuma
    "Development of acyclic nucleic acid incorporating pseudocomplementary bases to promote hybridization with RNA"
    Fuminori Sato, Keiji Murayama, Yukiko Kamiya, Hiroyuki Asanuma
    "Serinol nucleic acid (SNA) based fluorescent probe for highly sensitive detection of RNA"
    Keiji Murayama, Zehua Liu, Hiroyuki Asanuma

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2020

Original Paper

  1. "Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-aTNA/RNA and SNA/RNA"
    Kamiya, Y.; Satoh, T.; Kodama, A.; Suzuki, T.; Murayama, K.; Kashida, H.; Uchiyama, S.; Kato, K.; Asanuma, H.
    Commun. Chem., 2020, 3, 156. DOI: 10.1038/s42004-020-00400-2
  2. "Investigation of strand selective interaction of SNA-modified siRNA with AGO2-MID"
    Kamiya, Y.; Takeyama, Y.; Mizuno, T.; Sato, F.; Asanuma, H.
    Int. J. Mol. Sci., 2020, 21, 5218. DOI: 10.3390/ijms21155218
  3. "Photo-regulated trajectories of gliding microtubules conjugated with DNA"
    Akter, M.; Keya, J.J.; Kabir, A.M.R.; Asanuma, H.; Murayama, K.; Sada, K.; Kakugo, A.
    Chem. Commun., 2020, 56, 7953-7956. DOI: 10.1039/d0cc03124k
  4. "A triplex-forming linear probe for sequence-specific detection of duplex DNA with high sensitivity and affinity"
    Chen, Y.; Murayama, K.; Kashida, H.; Kamiya, Y.; Asanuma, H.
    Chem. Commun., 2020, 56, 5358-5361. DOI: 10.1039/D0CC01865A
    Selected as a "Back Cover"
  5. "Efficient Light-harvesting Antenna Results from Densely Organizing Dyes into a DNA Junction via D-threoninol"
    Kashida, H.; Azuma, H.; Maruyama, R.; Araki, Y.; Wada, T.; Asanuma, H.
    Angew. Chem. Int. Ed., 2020, 59, 11360-11363. DOI: 10.1002/anie.202004221
  6. "Incorporation of Pseudo-complementary Bases 2,6-Diaminopurine and 2-Thiouracil into Serinol Nucleic Acid (SNA) to Promote SNA/RNA Hybridization"
    Kamiya, Y.; Sato, F.; Murayama, K.; Kodama, A.; Uchiyama, S.; Asanuma, H.
    Chem. Asian J., 2020, 15, 1266-1271. DOI: 10.1002/asia.201901728
    Selected as a "Cover Picture"
  7. "A Quencher‐Free Linear Probe from Serinol Nucleic Acid with a Fluorescent Uracil Analogue"
    Murayama, K.; Asanuma, H.
    ChemBioChem, 2020, 21, 120-128. DOI: 10.1002/cbic.201900498
    Selected as a "Cover Feature"

Presentations

  1. Program Conference CLiC digital summer school (Aug. 18, On line at Frankfurt, Germany)
    [Invited lecture]
    "How far can we escape from DNA?"
    Hiroyuki Asanuma

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2019

Original Paper

  1. "8-Pyrenylvinyl Adenine Controls Reversible Duplex Formation between Serinol Nucleic Acid and RNA by [2+2] Photocycloaddition"
    Murayama, K.; Yamano, Y.; Asanuma, H.
    J. Am. Chem. Soc., 2019, 141, 9485-9489. DOI: 10.1021/jacs.9b03267
    Selected as a "Supplementary Cover"
  2. "Selective binding of nucleosides to gapped DNA duplex revealed by orientation and distance dependence of FRET"
    Kashida, H.; Kokubo, Y.; Makino, K.; Asanuma, H.
    Org. Biomol. Chem., 2019, 17, 6786-9789. DOI: 10.1039/C9OB00946A
    Selected as a "Front Cover"
  3. "cis-on/trans-off of DNA hybridization with alkylthio-azobenzene on L-threoninol responding to visible light"
    Asanuma, H.; Ishikawa, T.; Yamano, Y.; Murayama, K.; Liang, X.
    ChemPhotoChem, 2019, 3, 418-424. DOI: 10.1002/cptc.201900060
    Selected as a "VIP"
    Selected as a "Cover Feature"
  4. "Orthogonally Photocontrolled Non-Autonomous DNA Walker"
    Skugor, M.; Valero, J.; Murayama, K.; Centola, M.; Asanuma, H.; Famulok, M.
    Angew. Chem. Int. Ed., 2019, 58, 6948-6951. DOI: 10.1002/anie.201901272
  5. "The Use of Serinol Nucleic Acids as Ultrasensitive Molecular Beacons"
    Murayama, K.; Kashida H.; Asanuma, H.
    Method in Molecular Biology, 2019, Vol. 1973, : Non-Natural Nucleic Acids.
  6. "Isothermal double-cycle catalytic system using DNAzyme and RNase H for highly selective one-pot detection of oligonucleotides"
    An, R.; Kawai, H.; Asanuma, H.; Komiyama, M.; Liang, X.
    Analyst, 2019, 144, 2773-2779. DOI: 10.1039/c8an02520g
  7. "In-stem molecular beacon targeted to a 5’-region of tRNA inclusive of the D arm that detects mature tRNA with high sensitivity"
    Miyoshi, Y.; Ohtsuki, T.; Kashida, H.; Asanuma, H.; Watanabe, K.
    PLOS ONE, 2019, 14(1), e0211505. DOI: 10.1371/journal.pone.0211505
  8. "N-Benzoyl-Protected Peptide Nucleic Acid (PNA) Monomers Expand the Range of Nucleobases Available for PNA-DNA Chimera"
    Inagaki, M.; Uematsu, R.; Mizutani, T.; Unabara D.; Araki, Y.; Sakamoto, S.; Kashida, H.; Nishijima, M.; Inoue, Y.; Asanuma, H.; Wada, T.
    Chem. Lett., 2019, 48, 341-344. DOI: 10.1246/cl.181048
  9. "Photo-regulatable DNA isothermal amplification by template-mediated ligation"
    Cheng, B.; Kashida, H.; Shimada, N.; Maruyama, A.; Asanuma, H.
    Chem. Commun., 2019, 55, 1080-1083. DOI: 10.1039/c8cc09218d

Presentations

  1. China-Japan Joint Interdisciplinary Symposium on Molecular Magnetic Materials (Dec. 27-29, Guangzhou, China)
    [Invited]
    "Photoresponsive XNAs for the photo-switching of bio- and nano-functions"
    Hiroyuki Asanuma
  2. The Fourth A3 Roundtable Meeting on Asia Chemical Probe Research Hub (Nov. 18-21, Sendai, Japan)
    [Invited]
    "Acyclic XNAs of controlled orthogonality towards DNA and RNA"
    Hiroyuki Asanuma
    [Oral]
    "Functional control of serinol nucleic acid (SNA) by reversible photocycloaddition of 8-pyrenylvinyladenine"
    Yuuhei Yamano
  3. ISNAC 2019 (Oct. 29-31, Koganei Civic Center, Tokyo)
    [Invited lecture]
    "Acyclic SNA and aTNA as a new class of XNA for bio- and nanotechnology"
    Hiroyuki Asanuma
    [Oral]
    "Photo-control of reversible duplex formation between SNA and RNA by [2+2] photocycloaddition of 8-pyrenylvinyl adenine"
    Keiji Murayama, Yuuhei Yamano, Hiroyuki Asanuma
  4. 15th Annual Meeting Of The OTS (Oct. 13-16, Holiday Inn Munich City Centre, Germany)
    [Poster]
    "SNA modification on siRNA and anti-miRNA oligonucleotide for improvement of their performance"
    Yukiko Kamiya, Jumpei Ariyoshi, Hiroshi Kamimoto, Yuka Donoshita, Junya Takai, Keiji Murayama, Hiroyuki Asanuma
    "Artificial Nucleic Acids Composed of Acyclic Backbone for Fluorescent Probe and Antisense Reagent"
    Keiji Murayama, Hiromu Kashida, Hiroyuki Asanuma
  5. 2019 International Research Forum on Biology and Medical Science (IRFBMS 2019) (Aug. 22-25, Taiwan)
    [Invited lecture]
    "DNA nanocapsule for photo-triggered drug release"
    Hiroyuki Asanuma
  6. 10th NTTH Joint Symposium (July 29-31, Hotel Hokke Club Hakodate)
    [Invited lecture]
    "DNA and XNA nanomachines powered by light irradiation"
    Hiroyuki Asanuma
    [Poster]
    "Liner Probe for Direct Visualization of Duplexed DNA"
    Yanglingzhi Chen
  7. Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC2019) (July 22-24, Port Island Campus, Konan Univ.)
    [Poster]
    "Design of Functional oligonucleotides with acyclic serinol derivatives"
    Hiroyuki Asanuma, Keiji Murayama, Yukiko Kamiya, Hiromu Kashida
    "Design of siRNA and anti-miRNA oligonucleotide by using acyclic nucleic acid"
    Yukiko Kamiya, Fuminori Sato, Jumpei Ariyoshi, Hiroshi Kamimoto, Yuka Donoshita, Keiji Murayama, Hiroyuki Asanuma
  8. Shenyang Pharmaceutical Symposium (June 27, Shenyang Pharmaceutical University)
    [Invited lecture]
    "Design of functional oligonucleotide with acyclic scaffold"
    Hiroyuki Asanuma
  9. World Chemistry Conference and Exhibition 2019 (WCCE-2019) (June 13-15, Brussels, Belgium)
    [Invited lecture]
    "Azobenzene-tethered DNA for photo-triggered nanocapsule for drug release"
    Hiroyuki Asanuma

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2018

Original Paper

  1. "Quantitative evaluation of energy migration between identical chromophores enabled by breaking symmetry"
    Kashida, H.; Kawai, H.; Maruyama, R.; Kokubo, Y.; Araki, Y.; Wada, T.; Asanuma, H.
    Communications Chemistry, 2018, 1, 91. doi.org/10.1038/s42004-018-0093-0
  2. "Bifacial nucleobases for hexaplex formation in aqueous solution"
    Kashida, H.; Hattori, Y.; Tazoe, K.; Inoue, T.; Nishikawa, K.; Ishii, K.; Uchiyama, S.; Yamashita, H.; Abe, M.; Kamiya, Y.; Asanuma, H.
    J. Am. Chem. Soc., 2018, 140, 8456-8462.
    Selected as a "Supplementary Journal Cover"
  3. "Development of visible light-responsive RNA scissors based on the 10-23 DNAzyme"
    Kamiya, Y.; Arimura, Y.; Ooi, H.; Kato, K.; Liang, X.G.; Asanuma, H.
    ChemBioChem, 2018, 19, 1305-1311. DOI: 10.1002/cbic.201800020
  4. "DNA-assisted swarm control in a biomolecular motor system"
    Keya, J.J.; Suzuki, R.; Kabir, A.M.R.; Inoue, D.; Asanuma, H.; Sada, K.; Hess, H.; Kuzuya, A.; Kakugo, A.
    Nat. Commun., 2018, 9, 453. DOI: 10.1038/s41467-017-02778-5

Review

  1. "The DNA duplex as an aqueous one-dimensional soft crystal scaffold for photochemistry."
    Asanuma, H.; Murayama, K.; Kamiya, Y.; Kashida, H.
    Bull. Chem. Soc. Jpn., 2018, 91, 1739-1748.

Presentations

  1. Functional Nucleic Acids: From Laboratory to Targeted Molecular Therapy (FNA Perth 2018), Nov. 22-24, 2018, Perth (Australia)
    [Plenary Lecture]
    "Totally acyclic XNAs for medical applications"
    Hiroyuki Asanuma
  2. XIX NOST-Organic Chemistry Conference (XIX-NOST-OCC), September 6-9, 2018, Hotel Grand Hyatt, Goa, India
    [Invited]
    "Azobenzene-Tethered DNA for Photo-Driven Nanomachine"
    Hiroyuki Asanuma
  3. International Symposium on Photochemistry (27th PhotoIUPAC), July 8-13, 2018, Dublin, Ireland
    [Oral]
    "Observation of orientation dependence of FRET by using DNA scaffold"
    Hiromu Kashida
    "Design of novel fluorescent probe with fluorescent nucleobase on artificial acyclic nucleic acid"
    Keiji Murayama, Hiroyuki Asanuma
  4. The International Conference of Layers, Films and Membranes for Green, Environmental and Biomedical Sciences (LFM2018), May 14-16, 2018, National Taiwan University of Science and Technology, Taipei (Tiwan)
    [Plenary Lecture]
    "DNA nanomachine and nanoarchitecture powered by light-irradiation"
    Hiroyuki Asanuma
  5. INTERNATIONAL CONGRESS ON PURE & APPLIED CHEMISTRY 2018 (ICPAC2018), March 7-10, 2018, Siem Reap, Cambodia
    [Invited]
    "Azobenzene-tethered DNA for the photo-regulation of DNA functions"
    Hiroyuki Asanuma
    "Orientation Dependent FRET as a Tool to Analyze DNA Structures"
    Hiromu Kashida
  6. the Pure and Applied Chemistry International Conference 2018 (PACCON 2018) Feb. 7-9, 2018, Hat Yai, Songkhla (Thailand)
    [Invited]
    "Light-driven DNA nanomachine with an azobenzene-tethered DNA as photon-engine"
    Hiroyuki Asanuma

Award

    Prof. Asanuma, H.
    The Chemical Society of Japan Award for Creative Work for 2017
    "Creation of functional oligonucleotide with nucleotide-analogues designed from acyclic scaffold"

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2017

Original Paper

  1. "DNA microcapsule for photo-triggered drug release system"
    Kamiya, Y.; Yamada, Y.; Muro, T.; Matsuura, K.; Asanuma, H.
    ChemMedChem, 2017, 12, 2016-2021. DOI: 10.1002/cmdc.201700512
    Selected as a "Front Cover"
  2. "Introduction of 2,6-diaminopurines into serinol nucleic acid (SNA) improves anti-miRNA performance"
    Kamiya, Y.; Donoshita, Y.; Kamimoto, H.; Murayama, K.; Ariyoshi, J.; Asanuma, H.
    ChemBioChem, 2017, 18, 1917-1922
  3. "Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes"
    Le, B. T.; Murayama, K.; Shabanpoor, F.; Asanuma, H.; Veedu, R. N.
    RSC Advances, 2017, 7, 34049-34052.
  4. "D-aTNA circuit orthogonal to DNA can be operated by RNA input via SNA"
    Murayama, K.; Nagao, R.; Asanuma, H.
    ChemistrySelect, 2017, 2(20), 5624-5627.
  5. "Chaperone polymer-assisted, photo-driven DNA strand displacement"
    Cheng, B.; Kashida, H.; Shimada, N.; Maruyama, A.; Asanuma, H.
    ChemBioChem, 2017, 18, 1568-1572. DOI: 10.1002/cbic.201700394
    Selected as a "Front Cover"
  6. "Orientation-dependent FRET system reveals differences in structures and flexibilities of nicked and gapped DNA duplexes"
    Kashida, H.; Kurihara, A.; Kawai, H.; Asanuma, H.
    Nucleic Acids Res., 2017, 45(11), e105
  7. "Effect of Methyl Group on Acyclic Serinol Scaffold for Tethering Dyes on DNA Duplex stability"
    Murayama, K.; Asanuma, H.
    ChemBioChem, 2017, 18, 142-149

Review

  1. "Development of pseudo base-pairs on D-threoninol which exhibit various functions."
    Kashida, H.; Asanuma, H.
    Bull. Chem. Soc. Jpn., 2017, 90, 475
  2. "Precise control of the orientation of chromophore assembly by using DNA duplex as a scaffold and its application to photochemistry"
    Asanuma, H.; Kashida, H.
    Solid State Physics, 2017, 52(3), 149-158
  3. "Development of pseudo base pairs which exhibits high DNA duplex stabilities and orthogonality."
    Kashida, H.; Asanuma, H.
    Japanese Journal of Polymer Science and Technology, 2017, accepted
  4. "Design of photo-functional oligonucleotide by "copolymerization" of natural nucleobases with base-surrogate prepared from acyclic scaffold."
    Asanuma, H.; Murayama, K.; Kamiya, Y.; Kashida, H.
    Polymer J., 2017, 49, 279-289

Presentations

  1. the Pure and Applied Chemistry International Conference 2018 (PACCON 2018) Feb. 7-9, 2018, Hat Yai, Songkhla (Thailand)
    [Invited]
    "Light-driven DNA nanomachine with an azobenzene-tethered DNA as photon-engine"
    Hiroyuki Asanuma
  2. International Conference on Natural and Artificial Molecular Machines (NAMM2018) Dec. 18-20, 2017, IIT Bombay (India)
    [Invited]
    "Light-driven molecular machines with azobenzene-tethered DNA"
    Hiroyuki Asanuma
  3. The Second International Symposium on Biofunctional Chemistry (ISBC2017), Dec. 14-16, 2017, Kyoto Univ. (Kyoto)
    [Invited]
    "Design of totally acyclic XNAs for medical applications"
    Hiroyuki Asanuma
    [Poster]
    "Acyclic artificial nucleic acid circuit for sensitive detection of RNA"
    Keiji Murayama, Ryuya Nagao, Hiroyuki Asanuma
    "Photo-regulation of SNA duplex stability by introducing modified nucleobases"
    Yuuhei Yamano, Keiji Murayama, Hiroyuki Asanuma
    "Photo-controllable DNA strand displacement facilitated by chaperon polymer"
    Bohao Cheng, Hiromu Kashida, Naohiko Shimada, Atsushi Maruyama, Hiroyuki Asanuma
  4. The 44th International Symposium on Nucleic Acids Chemistry (ISNAC2017)(Nov. 14th to Nov. 16th, Tokyo University of Science)
    [Poster]
    "Light-driven non-toehold DNA strand displacement assisted by chaperone polymer"
    Bohao Cheng, Hiromu Kashida, Naohiko Shimada, Atsushi Maruyama, Hiroyuki Asanuma
    "Development of anti-miR oligonucleotide by using serinol nucleic acid and 2,6-diaminopurines"
    Yukiko Kamiya, Yuka Donoshita, Hiroshi Kamimoto, Keiji Murayama, Jumpei Ariyoshi, Hiroyuki Asanuma
  5. 1st Minisymposium on Material Biology (Oct.16-17, 2017, Tokyo institute of Technology)
    [Invited]
    "SNA and iL-aTNA for nucleic acid medicine"
    Hiroyuki Asanuma
  6. FIBER International Summit for Nucleic Acids 2017 (FISNA2017)(Jul. 19-21, Kobe)
    [Invited]
    "Orientation-dependent FRET in DNA duplex"
    Hiroyuki Asanuma
  7. Nagoya Univ.-Tsinghua Univ.-Toyota Motor Corp.-Hokkaido Univ. Joint Symposium(Jul. 12-14, Takayama)
    [Invited]
    "Orientation-Dependent FRET in DNA Duplex for Structural Analysis of Secondary Structure in Solution"
    Hiroyuki Asanuma
    [Poster]
    "Effect of the chirality of acyclic nucleic acid on its binding affinity for natural nucleic acids"
    Keiji Murayama, Hiromu Kashida, Hiroyuki Asanuma
    "Development of photo-responsive SNA by introduction of artificial modified nucleobases"
    Yuhei Yamano, Keiji Murayama, Hiroyuki Asanuma
  8. The 5th International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions (Jan. 21-22, Tokyo, Japan)
    "Development of Acyclic Artificial Nucleic Acids for Biological Tools"[Poster]
    Keiji Murayama, Yukiko Kamiya, Hiromu Kashida, Hiroyuki Asanuma

Award

    Dr. Kashida, H.
    The Young Scientists’ Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Japan (2017)

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2016

Original Paper

  1. "Dynamics of Inter-DNA Chain Interaction of Photoresponsive DNA"
    Nakasone, Y.; Ooi; H.; Kamiya, Y.; Asanuma, H.; Terazima, M.
    J. Am. Chem. Soc., 2016, 138, 9001-9004
  2. "Strand-invading linear probe combined with unmodified PNA"
    Aasanuma, H.; Niwa, R.; Akahane, M.; Murayama, K.; Kashida, H.; Kamiya, Y.
    Bioorg. Med. Chem., 2016, 24, 4129-4137. DOI:10.1016/j.bmc.2016.06.055
  3. "Visible Light-Triggered Crosslinking of DNA Duplex by Reversible [2+2] Photocycloaddition of Styrylpyrene"
    Doi, T.; Kawai, H.; Murayama, K.; Kashida, H.; Asanuma, H.
    Chem. Eur. J., 2016, 22, 10533-10538
  4. "A stem-less probe using spontaneous pairing between Cy3 and quencher for RNA detection"
    Kashida, H.; Morimoto, K.; Asanuma, H.
    Sci. Technol. Adv. Mater., 2016, 17, 267-273
  5. "Faint electric treatment-induced rapid endosomal escape for efficient delivery of functional macromolecules into the cytoplasm"
    Hasan, M.; Nishimoto, A.; Ohgita, T.; Hama, S.; Kashida, H.; Asanuma, H.; Kogure, K.
    J. Control Release, 2016, 228, 20-25

Review

  1. "Acyclic artificial nucleic acids with phosphodiester bonds exhibit unique functions"
    Kashida, H.; Murayama, K.; Asanuma, H.
    Polymer J., 2016, 48, 781-786

Presentations

     
  1. The 11th SPSJ International Polymer Conference (IPC 2016) (Dec. 13-16, Fukuoka, Japan)
    "Accumulation of dyes into DNA for efficient light-harvesting"【Oral】
    Hiromu Kashida, Ryoko Maruyama, Hayato Kawai, Yasuyuki Araki, Takehiko Wada and Hiroyuki Asanuma
    "Structural analysis of modified DNA by using FRET system"【Poster】
    Hayato Kawai, Tetsuya Doi, Hiromu Kashida and Hiroyuki Asanuma
  2. The 20th ISIR International Symposium “Molecular Technology Frontiers towards IoT world” (Dec. 12-13, Osaka, Japan)
    "Programmable Artificial Nucleic Acids for Bio-application"【Invited lecture】
    Hiroyuki Asanuma
  3. AsiaNANO 2016 Asian Conference on Nanoscience & Nanotechnology 2016 (Oct. 10-13, Sapporo, Japan)
    "L-aTNA as a novel acyclic nucleic acid for the recognition of natural nucleic acids"【Oral】
    Keiji Murayama, Hiromu Kashida, Hiroyuki Asanuma
  4. Beilstein Organic Chemistry Symposium 2016 Nucleic Acid Chemistry (Oct. 5-7, Prien (Chiemsee), Germany)
    "D-L-aTNA and SNA as a new class of acyclic XNA"【Invited】
    Hiroyuki Asanuma
  5. The First Roundtable Meeting on Chemical Probe Research Hub(Sept. 22-24, Fukuoka, Japan)
    "Physics in DNA(4); [2+2] photodimerization of stilbene derivatives within the DNA duplex"【Invited】
    Hiroyuki Asanuma, Tetsuya Doi, Hiromu Kashida
  6. The 43rd International Symposium on Nucleic Acid Chemistry (ISNAC2016)
    (Sep. 27-29, Kumamoto)

    [Oral]
    "Structural analyses of nicked and gapped DNA duplexes by using orientation dependence of FRET"
    Hiromu Kashida, Ayako Kurihara, Hiroyuki Asanuma
    "Development of super-sensitive Fluorescent probe composed of SNA for monitoring of RNA in living cell"
    Keiji Murayama, Yukiko Kamiya, Hiromu Kashida, Hiroyuki Asanuma
    [Poster]
    "Signal amplification by DNAzyme combined with RNase H"
    Ran An, Hayato Kawai, Hiroyuki Asanuma, Xingguo Liang
  7. 3rd Fluorescent Biomolecules and Their Building Blocks Design and Applications (FB3) (July 7-11, Tianjin, China)
    "Orientation-dependent FRET in DNA duplex"【Invited】
    Hiroyuki Asanuma
  8. FIBER International Summit for Nucleic Acids 2016 (FISNA2016) (July 6-8, Kobe, Japan)
    "Tracing the “Fate” of siRNA"【Invited】
    Hiroyuki Asanuma

Award

    Prof. Asanuma, H.
    The Award of the Society of Polymer Science, Japan (2015)
    "Creation of Photo-Functional Nanomaterials with Artificial Nucleotides Designed from Acyclic Scaffolds"

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2015

Original Paper

  1. "Terminus-free siRNA prepared by photo-crosslinking activated via slicing by Ago2"
    Kamiya, Y.; Iishiba, K.; Doi. T.; Tsuda, K.; Kashida, H.; Asanuma, H.
    Biomater. Sci., 2015, 3, 1534-1538
    Selected as a "Back cover"
  2. "Azobenzene C-nucleosides for photo-controlled hybridization of DNA at room temperature"
    Goldau, T.; Murayama, K.; Brieke, C.; Asanuma, H., Heckel, A.
    Chem. Eur. J., 2015, 21, 17870-17876, DOI : 10.1002/chem.201503303
  3. "Hetero-Selective DNA-like Duplex Stabilized by Donor-Acceptor Interaction"
    Doi, T.; Sakakibara,T.; Kashida, H.; Araki, Y.; Wada, T.; Asanuma, H.
    Chem. Eur. J., 2015, 21, 15974-15980. DOI: 10.1002/chem.201502653
    Selected as a "Frontispiece"
  4. "Ultra-Sensitive Molecular Beacon Designed with Totally Serinol Nucleic Acid (SNA) for Monitoring mRNA in Cell"
    Murayama, K.; Kamiya, Y.; Kashida, H.; Asanuma, H.
    ChemBioChem, 2015, 16, 1298-1301, DOI: 10.1002/cbic.201500167
  5. "Molecular design of Cy3 derivative for highly sensitive in-stem molecular beacon and its application to the wash-free FISH"
    Kashida, H.; Osawa, T.; Morimoto, K.; Kamiya, Y.; Asanuma, H.
    Bioorg. Med. Chem., 2015, 23, 1758-1762
  6. "Efficiency of [2+2] photodimerization of various stilbene derivatives within the DNA duplex scaffold"
    Doi, T.; Kashida, H.; Asanuma, H.
    Org. Biomol. Chem., 2015, 13, 4430-4437
    Selected as a "Front Cover"
  7. "Highly sensitive and robust linear probe for detection of mRNA in cells"
    Asanuma, H.; Akahane, M.; Niwa, R.; Kashida, H.; Kamiya, Y.
    Angew. Chem. Int. Ed., 2015, 54, 4315-4319
  8. "Acyclic L-Threoninol Nucleic Acid (L-aTNA) with Suitable Structural Rigidity Cross-pairs with DNA and RNA."
    Murayama, K.; Kashida, H.; Asanuma, H.
    Chem. Commun., 2015, 51, 6500-6503
    Selected as a "Back Cover"
  9. "Reversible photoswitching of RNA hybridization at room temperature with an azobenzene C-nucleoside."
    Goldau, T.; Murayama, K.; Brieke, C. Steinwand, S.; Mondal, P.; Biswas, M.; Burghardt, I.; Wachtveitl, J.; Asanuma, H.; Heckel, A.
    Chem. Eur. J., 2015, 21, 2845-2854.
  10. "Synthetic gene involving azobenzene-tethered T7 promoter for the photocontrol of gene expression by visible light."
    Kamiya, Y.; Takagi, T.; Ooi, H.; Ito, H.; Liang, X.G.; Asanuma, H.
    ACS Synth. Biol., 2015, 4, 365-370.

Reviews

  1. "Pre-organized guide RNA in Cas9 complex is ready for selection of the target double-stranded DNA"
    Kamiya, Y.; Asanuma, H.
    ChemBioChem, 2015, 16, 2273-2275
  2. "Reversible photo-switching of DNA fuction with azobenzene-tethered DNA"
    Kamiya, Y.; Asanuma, H.
    The Glen Report, 2015, 27, 1-3
  3. "RNA imaging by using a novel artificial nucleic acid, SNA"
    Kashida, H.; Murayama, K.; Asanuma, H.
    SEITAI NO KAGAKU, 2015, 66(2), 145-150.

Presentation

  1. Pacifichem2015 (Dec. 15-20, Honolulu, U.S.A.)
    【Oral】
    "Control of the chirality and helicity of artificial duplex by sequence design"
    H. Asanuma, K. Murayama, H. Kashida
    "Stemless linear probe for the detection of RNA in living cell"【Invited】
    H. Asanuma, M. Akahane, R. Niwa, Y. Kamiya, H. Kashida
    "Development of hetero-selective pseudo base pair stabilized by charge-transfer interaction, and its hetero-duplex formation"
    T. Doi, T. Sakakibara, H. Kashida, H. Asanuma
    "Fluorescent monitoring of siRNA by modification with dye pairs in cell"
    Y. Kamiya, A. Ito, and H. Asanuma
    "Design of an ultra-sensitive fluorescent probe composed of artificial nucleic acid for visualization of RNA in living cell"
    K. Murayama, Y. Kamiya, H. Kashida, H. Asanuma
    【Poster】
    "Development of orientation-dependent FRET system for structural analyses of nucleic acids"
    H. Kashida, A. Kurihara, H. Asanuma
  2. 9th International Symposium on Nanomedicine (ISNM2015) (Dec. 10-12, Mie, Japan)
    【Oral】
    "Fluorescent monitoring of intracellular trafficking of siRNA"【Invited】
    Yukiko Kamiya
  3. International Symposium on EcoTopia Science (ISETS'15) (Nov. 21-23, Nagoya, Japan)
    【Oral】
    "Fluorescent tracing of siRNA in living cell"
    H. Asanuma, A. Ito, and Y. Kamiya
    "Development of photoresponsive microcapsule made by DNA"
    Y. Kamiya, Y. Yamada, T. Muro, K. Matsuura, H. Asanuma
    【Poster】
    "Design of novel acyclic artificial nucleic acid for improvement of affinity for natural nucleic acids"
    K. Murayama, Y. Kamiya, H. Kashida, and H. Asanuma
  4. BIT's 6th World Gene Convention-2015 (Nov. 13-15, Qingdao, China)
    "Stemless linear probe for detecting mRNA in living cell"【Invited】
    H. Asanuma, M. Akahane, Y. Kamiya, H. Kashida
    "Development of a robust FRET system for structural analyses of DNA duplexes"【Invited】
    H. Kashida, A. Kurihara, H. Asanuma
  5. International Conference on Small Science 2015 (ICSS-2015)
    (Nov. 4-7, Phuket, Thailand)

    "RNA detection in living cell with super-sensitive linear probe"【Invited】
    Hiroyuki Asanuma
  6. The 42nd International Symposium on Nucleic Acid Chemistry (ISNAC2015)
    (Sep. 23-25, Himeji)

    [Oral]
    "L-aTNA as a new acyclic nucleic acid for the recognition of DNA and RNA"
    Keiji Murayama, Hiromu Kashida, Hiroyuki Asanuma
    "Fluorescent imaging of intracellular trafficking of siRNA"
    Yukiko Kamiya, Anna Ito, Hiroyuki Asanuma
    [Poster]
    "Hetero-selective artificial duplex stabilized by charge-transfer interaction of pyrene/anthraquinone residues"
    Tetsuya Doi, Takumi Sakakibara, Hiromu Kashida, Yasuyuki Araki, Takehiko Wada, Hiroyuki Asanuma
    "Structural analysis of gapped DNA duplex by using orientation dependent FRET system"
    Hiromu Kashida, Ayako Kurihara, Hiroyuki Asanuma
  7. The 3rd China-Japan Symposium on Nanomedicine (Jun. 19-20th, Beijing)
    "Tracing the “fate” of siRNA" 【Invited】
    Yukiko Kamiya, Anna Ito, and Hiroyuki Asanuma
  8. The 6th Taiwan-Japan Symposium on Nanomedicine
    (Jan. 8-9th, Academia Sinica, Taipei, Taiwan)

    [Poster]
    "Development of In Stem Molecular Beacons for Sensitive RNA Detection"
    Hiromu Kashida, Kazuhiro Morimoto, Keiji Murayama, Yukiko Kamiya, Hiroyuki Asanuma

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2014

Original Papers

  1. "Highly specific DNA detection from massive background nucleic acids based on rolling circle amplification of target dsDNA"
    Wang, X.; Yu, X.; Wand, X.; Suzuki, M.; Asanuma, H.; Dong, P.; Wu, W.; Liang, X.G.
    RSC Adv., 2014, 4, 38293-38299.
  2. "Enhancement of stability and activity of siRNA by terminal substitution with Serinol Nucleic Acid (SNA)."
    Kamiya, Y.; Takai, J.; Ito, H.; Murayama, K.; Kashida, H.; Asanuma, H.
    ChemBioChem, 2014, 15, 2549-2555.
    Selected as "Back Cover"

Reviews

  1. "Orientation-dependent FRET by use of DNA as a scaffold"
    Asanuma, H.; Kurihara, A.; Kashida, H.
    Photochemistry, 2014, 45, 146-147.
  2. "De Novo Design of Functional Oligonucleotides with Acyclic Scaffolds"
    Asanuma, H.; Kashida, H.; Kamiya, Y.
    Chem. Rec., 2014, 14, 1055-1069.
  3. "Light-driven DNA nanomachine with a photoresponsive molecular engine."
    Kamiya, Y.; Asanuma, H.
    Accounts of Chemical Research, 2014, 47, 1663-1672.

Presentations

  1. 7th Korea-Japan Seminars on Biomolecular Sciences:Experiments and Simulations
    (Nov. 26-28, KIAS, Seoul, Korea)

    "Photoregulation of gene expression with functional oligonucleotide involving azobenzene derivatives"【Invited】
    Yukiko Kamiya
  2. The 41st International Symposium on Nucleic Acid Chemistry (ISNAC2014)
    (Nov. 5-7, Kitakyusyu International Conference Center)

    [Oral]
    "Structural analysis of dye-modified DNA duplex by using FRET"
    Hiromu Kashida, Ayako Kurihara, and Hiroyuki Asanuma
    "Photo-triggered collapse of 3D microsphere by photo-driven DNA nanodevice"
    Yukiko Kamiya,Yoshinobu Yamada, Takahiro Muro, Xingguo Liang, Kazunori Matsuura, and Hiroyuki Aasanuma
    [Poster]
    "Photodimerization reactivity evaluation of stilbene derivatives by using DNA duplex as a scaffold"
    Tetsuya Doi, Takumi Sakakibara, Hiromu Kashida, and Hiroyuki Asanuma
  3. 20th International Conference on DNA computing and Molecular Programming (DNA20) (September 22-26, Kyoto Univ.)
    [Oral]
    "Light-powered DNA nanomachine carrying azobenzenes as molecular photon-engine"【Invited】
    Hiroyuki Asanuma
    [Poster]
    "Light-triggered signal conversion of DNA to RNA"
    Yukiko Kamiya, Toshiki Takagi, Hiroshi Ito, Xingguo Liang and Hiroyuki Asanuma
    "Photoregulated collapse of 3D microstructure by photo-driven DNA nanodevice"
    Yoshinobu Yamada, Takahiro Muro, Xingguo Liang, Kazunori Matsuura, Yukiko Kamiya, and Hiroyuki Aasanuma
  4. 1st International Caparica Conference on Chromogenic and Emissive Materials.(September 8-10, Caparica, Portugal)
    "Stemless linear probe with multiple fluorophores on D-threoninols for thefluorescent imaging of m-RNA in cell."【Invited】
    Hiroyuki Asanuma, Mariko Akahane, Hiromu Kashida, Yukiko Kamiya
  5. XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids (August 24-28, Pozna , Poland)
    "Intracellular Monitoring of siRNA by Conjugation of Fluorescent Probe"
    Yukiko Kamiya, Anna Ito, Hiroshi Ito, Masaaki Urushihara, Junya Takai, Taiga Fujii, Xingguo Liang, Hiromu Kashida, and Hiroyuki Asanuma
  6. China/Japan Young Chemists Forum (August 5, Beijing, China)
    "Highly-sensitive RNA detection by using In Stem Molecular Beacon"【Invited】
    Hiromu Kashida
  7. From Duplexes to Quadruplexes Understanding DNA Structure and Function (July 3, 2014, Reading, UK)
    "de novo Design of functional oligonucleotide with acyclic scaffold"【Invited】
    Hiroyuki Asanuma
  8. XVIth Symposium on Chemistry of Nucleic Acid Components(SCNAC2014)(June 9-13, esky Krumlov, Czech)
    "Orientation-dependent FRET between the intercalated donor and acceptor fluorophores"
    Hiromu Kashida, Ayako Kurihara, Tomohiro Kato, and Hiroyuki Asanuma
    "Development of an ultra-sensitive fluorescent probe composed of artificial nucleic acid for the detection of mRNA in cell"
    Keiji Murayama, Yukiko Kamiya, Hiromu Kashida and Hiroyuki Asanuma

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2013

Original Papers

  1. "Selective labeling of mature RISC using siRNA carrying fluorophore-quencher pair."
    Kamiya, Y.; Ito, A.; Ito, H.; Urushihara, M.; Takai, J.; Fujii, T.; Liang, X.G.; Kashida, H.; Asanuma, H.
    Chem. Sci., 2013, 4, 4016-4021.
  2. "The “sugar-deficient” G-quadruplex: incorporation of aTNA in quadruplex structures."
    Zhou, J.; Murayama, K.; Amrane, S.; Kashida, H.; Bourdoncle, A.; Asanuma, H.; Mergny, J. L.
    Chem. Sci., 2013, 4, 3693-3698.
  3. "Highly stable duplex formation by artificial nucleic acids aTNA and SNA with acyclic scaffolds."
    Murayama, K.; Tanaka, Y.; Toda, T.; Kashida, H.; Asanuma, H.
    Chem. Eur. J., 2013, 19, 14151-14158.
  4. "p-Stilbazole moieties as artificial base pairs for photocrosslinking of DNA duplex."
    Kashida, H.; Doi, T.; Sakakibara, T.; Hayashi, T.; Asanuma, H.
    J. Am. Chem. Soc., 2013, 135, 7960-7966.
  5. "Evaluation of intrinsic spectroscopic properties of chromophore assemblies by shielding with cyclohexyl base pairs within a DNA duplex."
    Kashida, H.; Higashiyama, N.; Kato, T.; Asanuma, H.
    Bioorg. Med. Chem., 2013, 21, 6191-6197.
  6. "Photoswitch nucleic acid catalytic activity by regulating topological structure with a universal supra-photoswitch"
    Liang, X.G.; Zhou, M.G.; Kato, K.; Asanuma, H.
    ACS Synth. Biol., 2013, 2, 194-202.
  7. "Development of a robust model system of FRET using base-surrogates tethering fluorophores for strict control of their position and orientation within DNA duplex."
    Kato, T.; Kashida, H.; Kishida, H.; Yada, H.; Okamoto, H.; Asanuma, H.
    J. Am. Chem. Soc., 2013, 135, 741-750.

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2012

Original Papers

  1. "A model of elongation of short DNA sequence by thermophilic DNA polymerase under isothermal conditions."
    Kato, T.; Liang, X. G.; Asanuma, H.
    Biochemistry, 2012, 51, 7846-7853.
  2. "Reversed assembling of dyes in RNA duplex compared with those in DNA"
    Fujii, T.; Urushihara, M.; Kashida, H.; Ito, H.; Liang, X.G.; Yagi-Utsumi, M.; Kato, K.; Asanuma, H.
    Chem. Eur. J., 2012, 18, 13304-13313.
    Selected as a "frontispiece"
  3. "Quencher-free linear probe with multiple fluorophores on acyclic scaffold"
    Asanuma, H.; Akahane, M.; Kondo, N.; Osawa, T.; Kato, T.; Kashida, H.
    Chem. Sci., 2012, 3, 3165-3169.
    Selected as an "Inside Back Cover"
  4. "Bulge-like asymmetric hetero dye-clustering in DNA duplex results in efficient quenching of background emission based on the maximized excitonic interaction"
    Fujii, T.; Hara, Y.; Osawa, T.; Kashida, H.; Liang, X.G.; Yoshida, Y.; Asanuma, H.
    Chem. Eur. J., 2012, 18, 10865-10872.
  5. "Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation"
    Kashida, H.; Yamaguchi K.; Hara, Y.; Asanuma, H.
    Bioorg. Med. Chem., 2012, 20, 4310-4315.
  6. "Coherent Interactions of Dyes Assembled on DNA" (Review)
    Asanuma, H.; Fujii, T.; Kato, T.; Kashida, H.
    J. Photochem. Photobiol. C, 2012, 13, 124-135.
  7. "Preparation of supramolecular chromophoric assemblies using a DNA duplex" (Perspective)
    Kashida, H.; Asanuma, H.
    Phys. Chem. Chem. Phys., 2012, 14, 7196-7204.
  8. "Design of an Artificial Functional Nanomaterial with High Recognition Ability"
    Liang, X. G.; Mochizuki, T.; Fujii, T.; Kashida, H.; Asanuma, H.
    Natural Computing, 2012, 11, 231-238.
  9. "Improvement of RNAi activity and strand-selectivity of RISC formation by modified siRNA involving intercalators near 5'-termini"
    Ito, H.; Urushihara, M.; Liang, X. G.; Asanuma, H.
    ChemBioChem, 2012, 13, 311-315.
  10. "Polycation-chaperoned in-stem molecular beacon system"
    Asanuma, H.; Osawa, T.; Kashida, H.; Fujii, T.; Liang, X. G.; Niwa, K.; Yoshida, Y.; Shimada, N.; Maruyama, A.
    Chem. Commun., 2012, 48, 1760-1762.
  11. "Photon-fueled DNA nanodevice carrying two different photoswitches."
    Nishioka, H.; Liang, X. G.; Kato, T.; Asanuma, H.
    Angew. Chem. Int. Ed., 2012, 51, 1165-1168.
  12. "Ultrafast photoisomerization and its single-shot pump pulse efficiency of trans-azobenzene derivative: Compound for photosensitive DNA."
    Chen, T.; Yamaguchi, A.; Igarashi, K.; Nakagawa, N.; Nishioka, H.; Asanuma, H.; Yamashita, M.
    Opt. Commun., 2012, 285, 1206-1211.

Books

  1. "Oligonucleotide Conjugates for Detection of Specific Nucleic Acid Sequences"
    Kashida, H.; Asanuma, H.
    "DNA Conjugates and Sensors" Eds. by K. R. Fox, T. Brown
    RSC Publishing, p.242-257, (2012).

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2011

Original Papers

  1. "Cyclohexyl “base pairs” stabilize duplexes and intensify pyrene fluorescence by shielding it from natural base pairs."
    Kashida, H.; Sekiguchi, K.; Higashiyama, N.; Kato, T.; Asanuma, H.
    Org. Biomol. Chem., 2011, 9, 8313-8320.
  2. "Femtosecond photoisomerization of azobenzene-derivative binding to DNA."
    Chen, T.; Igarashi, K.; Nakagawa, N.; Yamane, K.; Fujii, T.; Asanuma, H.; Yamashita, M.
    J. Photochem. Photobiol. A, 2011, 223, 119-123.
  3. "Nick Sealing by T4 DNA Ligase on a Modified DNA Template Tethering a Functional Molecule on D-Threoninol."
    Liang, X. G.; Fujioka, K.; Asanuma, H.
    Chem. Eur. J., 2011, 17, 10388-10396.
  4. "Preparation of photoresponsive DNA tethering ortho-methylated azobenzene as a supraphotoswitch."
    Asanuma, H.; Nishioka, H.; Ishikawa, T.; Liang, X. G.;
    Current Protocols in Nucleic Acid Chemistry, 2011, 4.45.1-4.45.18.(DOI: 10.1002/0471142700.nc0445s46)
  5. "Detection of three-base deletion by exciplex formation with perylene derivatives."
    Kashida, H.; Kondo, N.; Sekiguchi, K.; Asanuma, H.
    Chem. Commun., 2011, 47, 6404-6406.
  6. "A Cationic dye triplet as a unique “glue” that can connect fully matched termini of DNA duplexes."
    Kashida, H.; Hayashi, T.; Fujii, T.; Asanuma, H.
    Chem. Eur. J., 2011, 17, 2614-2622.
    Selected as a "VIP"
    Selected as an "Inside Cover"
  7. "Control of the Chirality and Helicity of Oligomers of Serinol Nucleic Acid (SNA) by Sequence Design."
    Kashida, H.; Murayama, K.; Toda, T.; Asanuma, H.
    Angew. Chem. Int. Ed., 2011, 50, 1285-1288.
    Selected as a "Hot Paper"
  8. "Design of a Functional Nanomaterial with Recognition Ability for Constructing Light-Driven Nanodevices."
    Liang, X.G.; Mochizuki, T.; Fujii, T.; Kashida, H.; Asanuma, H.
    LNCS 2011, 6518, 112-122.

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2010

Original Papers

  1. "Unexpectedly stable artificial duplex from flexible acyclic threoninol."
    Asanuma, H.; Toda, T.; Murayama, K.; Liang, X.G.; Kashida, H.
    J. Am. Chem. Soc., 2010, 132, 14702-14703.
  2. "Construction of photoresponsive RNA for photoswitching RNA hybridization."
    Ito, H.; Liang, X.G.; Nishioka, H.; Asanuma, H.
    Org. Biomol. Chem., 2010, 8, 5519-5524.
  3. "Robust and photo-controllable DNA capsules using azobenzenes."
    Tanaka, F.; Mochizuki, T.; Liang, X.G.; Asanuma, H.; Tanaka, S.; Suzuki, K.; Kitamura, S.; Nishikawa, A.; Ui-Tei, K.; Hagiya, M.
    Nano Lett., 2010, 10, 3560-3565.
  4. "Insulator base pairs for lighting-up perylenediimide in a DNA duplex."
    Kashida, H.; Sekiguchi, K.; Asanuma, H.
    Chem. Eur. J., 2010, 16, 11554-11557.
  5. "Coherent Quenching of a Fluorophore for the Design of a Highly Sensitive In-Stem Molecular Beacon."
    Hara, Y.; Fujii, T.; Kashida, H.; Sekiguchi, K.; Liang, X. G.; Niwa, K.; Takase, T.; Yoshida, Y.; Asanuma, H.
    Angew. Chem. Int. Ed., 2010, 49, 5502-5506.
  6. "Accumulation of fluorophores into DNA duplexes to mimic the properties of quantum dots."
    Kashida, H.; Sekiguchi, K.; Liang, X. G.; Asanuma, H.
    J. Am. Chem. Soc., 2010, 132, 6223-6230.
  7. "Photoregulation of DNA transcription by using photoresponsive T7 promoters and clarification of its mechanism."
    Liang, X.G.; Wakuda, R.; Fujioka, K.; Asanuma, H.
    FEBS J. 2010, 277, 1551-1561.
    Selected as "Front Cover"
  8. "A light-driven DNA nanomachine for efficiently photoswitching RNA digestion."
    Zhou M.G.; Liang, X.G.; Mochizuki, T.; Asanuma, H.
    Angew. Chem. Int. Ed. 2010, 49, 2167-2170.
    Selected as "Hot paper"
    Highlighted in Chemistry World
    Highlighted in Nature, 2010, 464, 10.
  9. "Effect of the ortho modification of azobenzene on the photoregulatory efficiency of DNA hybridization and thermal stability of its cis-form."
    Nishioka H.; Liang, X.G.; Asanuma, H.
    Chem. Eur. J. 2010, 16, 2054-2062.
  10. "An efficient Fluorescent Resonance Energy Transfer (FRET) between pyrene and perylene assembled in a DNA duplex and its potential for discriminating single base changes."
    Kashida, H.; Takatsu,T.; Sekiguchi, K.; Asanuma, H.
    Chem. Eur. J., 2010, 16, 2479-2486.
  11. "An interstrand-wedged duplex composed of alternating DNA base pairs and covalently attached intercalators."
    Liang, X.G.; Nishioka H.; Mochizuki, T.; Asanuma, H.
    J. Mater. Chem. 2010, 20, 575-581.
  12. "Molecular imprinting of cyclodextrin to physiologically active oligopeptides in water."
    Song, S.H.; Shirasaka, K.; Hirokawa, Y.; Asanuma, H.; Wada, T.; Sumaoka, J.; Komiyama, M.
    Supramol. Chem. 2010, 22, 149-155.

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2009

Original Papers

  1. "In-Stem Molecular Beacon containing a Pseudo Base Pair of Threoninol Nucleotides for the Removal of Background Emission."
    Kashida, H.; Takatsu, T.; Fujii, T.; Sekiguchi, K.; Liang, X. G.; Niwa, K.; Takase, T.; Yoshida, Y.; Asanuma, H.
    Angew. Chem. Int. Ed., 2009, 48, 7044-7047.
  2. "Modulation of pKa of Brooker’s Merocyanine by DNA Hybridization."
    Kashida, H.; Sano, K.; Hara, Y.; Asanuma, H.
    Bioconjugate Chem., 2009, 20, 258-265.
  3. "Photoisomerization dynamics study on cis-azobenzene derivative using ultraviolet-to-visible tunable femtosecond pulses."
    Yamaguchi, N.; Nagasawa, N.; Igarashi, K.; Sekikawa, T.; Nishioka, H.; Asanuma, H.; Yamashita, M.
    Appl. Surf. Sci. 2009, 255, 9864-9868.
  4. "A Supra-Photoswitch Involving Sandwiched DNA Base Pairs and Azobenzenes for Light-Driven Nanostructures and Nanodevices."
    Liang, X.G.; Mochizuki, T.; Asanuma, H.
    Small 2009, 5, 1761-1768.
    Selected as "Front Cover"
  5. "Construction of Photon-Fueled DNA Nanomachines by Tethering Azobenzenes as Engines."
    Liang, X.G.; Nishioka, H.; Takenaka, N.; Asanuma, H.
    LNCS 2009, 5347, 21-32.
  6. "Analysis of Coherent Heteroclustering of Different Dyes by Use of Threoninol Nucleotides for Comparison with the Molecular Exciton Theory."
    Fujii, T.; Kashida H.; Asanuma, H.
    Chem. Eur. J., 2009, 15, 10092-10102.
  7. "Positively charged base surrogate for highly stable “base pairing” through electrostatic and stacking interactions."
    Kashida, H.; Ito, H.; Fujii, T.; Hayashi, T.; Asanuma H.
    J. Am. Chem. Soc., 2009, 131, 9928-9930.
  8. "Glucuronidase-assisted transglycosylation for the synthesis of highly functional disaccharides: β-D-Glucuronyl 6-O-sulfo-β-D-gluco- and -β-D-Galactopyranosides."
    Nagatsuka T.; Uzawa H.; Asanuma H., Nishida, Y.
    J. Carbohydrate Chem. 2009, 28, 94-106.
  9. "Efficient energy transfer from pyrene to perylene assembled inside DNA duplex."
    Kashida, H.; Takatsu, T.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2009, 53, 29-30.
  10. "Line up base pairs and intercalators one by one in a stable duplex."
    Liang, X.G.; Mochizuki T.; Nishioka H.; Asanuma, H.
    Nucleic Acids Symp. Ser. 2009, 53, 189-190.

Reviews

  1. "Rational design of functional DNA with a non-ribose acyclic scaffold"
    Kashida, H.; Liang, X.G.; Asanuma, H.
    Curr. Org. Chem., 2009, 13, 1065-1084.

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2008

Original Papers

  1. "Postsynthetic modification of DNA via threoninol on a solid support by means of allylic protection."
    Asanuma, H.; Hara, Y.; Noguchi, A.; Sano, K.; Kashida, H.
    Tetrahedron Lett.., 2008, 49, 5144-5146.
  2. "A DNA Nanomachine Powered by Light Irradiation."
    Liang, X.G.; Nishioka, H.; Takenaka, N.; Asanuma, H.
    ChemBioChem, 2008, 9, 702-705.
  3. "Molecular Design for Reversing the Photoswitching Mode of Turning ON and OFF DNA Hybridization"
    Liang, X.G.; Takenaka, N.; Nishioka, H.; Asanuma, H.
    Chem. Asian J., 2008, 3, 553-560.
  4. "Threoninol as a Scaffold of Dyes (Threoninol-nucleotide) and Their Stable Interstrand Clustering in Duplexes."
    Kashida, H.; Fujii, T.;Asanuma, H.
    Org. Biomol. Chem., 2008, 6, 2892-2899.
  5. "Diastereomer Separation of Azobenzene-Tethered Oligodeoxyribonucleotides and Determination of Their Absolute Configurations by Enzymatic Digestion."
    Liang, X. G.; Komiyama, M.; Asanuma, H.
    Nucleosides, Nucleotides & Nucleic Acids, 2008, 27, 332-350.
  6. "Construction of a photo-switchable gene for turning on and off gene expression with light irradiation."
    Liang, X.G.; Fujioka, K.; Tsuda, Y.; Wakuda, R.; Asanuma, H.
    Nucleic Acids Symp. Ser. 2008, 52, 19-20.
  7. "Light driven open/close operation of an azobenzene-modified DNA nano-pincette."
    Liang, X.G.; Takenaka, N.; Nishioka, H.; Asanuma, H.
    Nucleic Acids Symp. Ser. 2008, 52, 697-698.
  8. "Incorporation of cationic dyes into DNA for distinct stabilization of duplex"
    Kashida, H.; Itoh, H.; Fujii, T.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2008, 52, 701-702.
  9. "Preparation of coherent hetero clusters with threoninol scaffold."
    Fujii, T.; Kashida, H.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2008, 52, 699-700.

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2007

Original Papers

  1. "Detection of genetic polymorphisms with high sensitivity by DNA-perylene conjugate."
    Kashida, H.; Takatsu, T.;Asanuma, H.
    Tetrahedron Lett., 2007, 48, 6759-6762.
  2. "Recognition of Solution Structures of Peptides by Molecularly Imprinted Cyclodextrin Polymers."
    Song, S.; Shirasaka, K.; Katayama, M.; Nagaoka, S.; Yoshihara, S.; Osawa, T.; Sumaoka, J.; Asanuma H., Komiyama, M.
    Macromolecules 2007, 40, 3530-3532.
  3. "2',6'-Dimethylazobenzene as an efficient and thermo-stable photo-regulator for the photoregulation of DNA hybridization."
    Nishioka, H.; Liang, X.G.; Kashida, H.; Asanuma, H.
    Chem. Commun., 2007, 4354-4356.
  4. "Synthesis of Azobenzene-Tethered DNA for Reversible Photo-Regulation of DNA."
    Asanuma, H.; Liang, X.G.; Nishioka, H.; Matsunaga, D.; Liu, M.Z.; Komiyama, M.
    Nat. Protoc., 2007, 2, 203-212.
  5. "Development of high-sensitive DNA probe by using perylene."
    Kashida, H.; Takatsu, T.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 279-280.
  6. "Construction of novel dye aggregates based on "comb-type" sequence."
    Kashida, H.; Fujii, T.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 11-12.
  7. "Preparation of "comb-type" hetero aggregates by DNA-dye conjugation."
    Fujii, T.; Kashida, H.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 277-278.
  8. "Photoregulation of DNA hybridization by introducing an azobenzene: Molecular design for more stabilization of DNA duplex with cis-azobenzene than with its trans-form."
    Liang, X.G.; Takenaka, N; Nishioka, H.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 169-170.
  9. "Unexpected efficient ab initio DNA synthesis at low temperature by using thermophilic DNA polymerase."
    Liang, X.G.; Kato, T.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 351-352.
  10. "Effective photoregulation of gene expression by photoresponsive T7 promoter."
    Liang, X.G.; Wakuda, R.; Tsuda, Y.; Nishioka, H.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 349-350.
  11. "Development of photoresponsive RNA towards photoswitching of RNA functions."
    Ito, H.; Nishioka, H.; Liang, X.G.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 171-172.
  12. "Design of peptide nucleic acid by introduction of carbohydrate on lysine linker."
    Noguchi, A.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2007, 51, 261-262.

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2006

Original Papers

  1. "Covalent Incorporation of Methyl Red Dyes into Double-Stranded DNA for Their Ordered Clustering"
    Kashida, H.; Tanaka, M.; Baba, S.; Sakamoto, T.; Kawai, G.; Asanuma, H.; Komiyama, M.
    Chem. -Eur. J., 2006, 12, 777-784.
  2. "Exciplex Formation between Pyrene and N,N-Dimethylaniline in DNA for the Detection of One-base Deletion."
    Kashida, H.; Komiyama, M.; Asanuma, H.
    Chem. Lett., 2006, 35, 934-935.
  3. "Insertion of two pyrene moieties into oligodeoxyribonucleotides for the efficient detection of deletion polymorphisms."
    Kashida, H.; Asanuma, H.; Komiyama, M.
    Chem. Commun., 2006, 2768-2770.
    (Highlighted in Chemical Biology, B29, 1 (2006))
  4. "Photo- and Thermoregulation of DNA Nanomachines."
    Takahashi, K.; Yaegashi, S.; Asanuma, H.; Hagiya, M.
    LNCS 2006, 3892, 336-346.
  5. "Azobenzene-tethered T7 promoter for Efficient Photoregulation of Transcription."
    Liu, M.; Asanuma, H.; Komiyama, M.
    J Am. Chem. Soc., 2006, 128, 1009-1015.
  6. "Enhancement of RNA Cleavage Activity of 10-23 DNAzyme by Covalently Introduced Intercalator."
    Asanuma, H.; Hayashi, H.; Zhao, J.; Liang, X.G.; Yamazawa, A.; Kuramochi, T.; Matsunaga, D.; Aiba, Y.; Kashida, H.; Komiyama, M.
    Chem. Commun., 2006, 5062-5064.
  7. "Improved Method of Molecular Imprinting of Cyclodextrin on Silica-gel Surface for the Preparation of Stable Stationary HPLC Phase."
    Matsui, T.; Osawa , T.; Shirasaka , K.; Katayama, M.; Hishiya, T.; Asanuma H., Komiyama, M.
    J. Inclu. Phenom. Macrocyclic Chem. 2006, 56, 39-44.
  8. "Importance of the position of vinyl group on beta-cyclodextrin for the effective imprinting of amino acid derivatives and oligopeptides in water."
    Osawa, T.; Shirasaka, K.; Matsui, T.; Yoshihara, S.; Akiyama, T.; Hishiya, T.; Asanuma, H.; Komiyama, M.
    Macromolecules, 2006, 39, 2460-2466.
  9. "Incorporation of Methyl Group on Azobenzene for the Effective Photo-Regulation of Hybridization and Suppression of Thermal Isomerization."
    Nishioka, H.; Kashida, H.; Komiyama, M.; Liang, X.G.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2006, 50, 85-86.
  10. "Activation of DNA Enzyme 10-23 by Tethering an Intercalator to Its Backbone."
    Hayashi, H.; Liang, X.G.; Zhao, J.; Komiyama, M.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2006, 50, 167-168.

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2005

Original Papers

  1. "Clear-cut photo-regulation of the formation and dissociation of the DNA duplex by modified oligonucleotide involving multiple azobenzenes"
    Asanuma, H.; Matsunaga, D.; Komiyama, M.
    Nucleic Acids Symp. Ser., 2005 49 35-36.
  2. "Design of Light-switchable Phage Promoter for Efficient Photo-regulation of Gene-expression"
    Liu, M.; Komiyama, M.; Asanuma, H.
    Nucleic Acids Symp. Ser., 2005 49 283-284.