KEY WORDS

Biological engineering, Biomedical engineering, Nanobiomaterial, Biomicrodevices, Peptide-array, Bioinformatics, Drug development, functional foods, cosmetics, Bio-alcohol, Magnetic nanoparticles, Tissue Engineering, BioMEMS, Cell-based assay, Peptides, Animal cell culture, iPS cells

NEWS

• [Research] May/2025 Nakamura et al., Construction of Contractile Human iPSC-Derived Skeletal Muscle Tissues on 96-Well Scale Microdevices, Journal of Bioscience and Bioengineering, accepted
• [Research] Apr/2025 Matsunaga et al., Enrichment and identification of pancreas lipase inhibitory peptides from food protein hydrolysate using group-selective peptide adsorption support, Journal of Chemical Engineering of Japan, accepted
• [Research] Apr/2025 Shimizu et al., Identification of soy-derived peptides with micelle disruption activity of secondary bile acids, Food Science & Nutrition, accepted
• [Research] Jan/2025 Endo et al., Identification of barley-derived peptides with angiotensin converting enzyme inhibitory activity, International Journal of Food Engineering, accepted
• [Research] Aug/2024 Nagai et al., Quercetin induces a slow myofiber phenotype in engineered human skeletal muscle tissues, The FASEB Journal, accepted
• [Research] Jul/2024 Fujii et al., Discovery of Fibroblast Growth Factor 2 -Derived Peptides for Enhancing Mice Skeletal Muscle Satellite Cell Proliferation, Biotechnology Journal , accepted
• [Research] Apr/2024 A review paper in Japanese was accepted in Functional Food Research.
• [Other] Mar/2024 Eight new members! Welcome to the Honda Lab.
• [Research] Feb/2024 Iriyama et al., Separation and enrichment of multiple bile acid micelle-disrupting peptides by adsorption/desorption process with heat-treated porous silica gels, Biochemical Engineering Journal, Accepted.
• [Award] Sep/2023 Yosuke KATAYAMA (M2) recieved a Student Best Presentation Award in the 75th Annual Meeting of the Society for Biotechnology, Japan.
• [Award] Aug/19/2023 Itsuki FUJII (M1) recieved a Student's Award in the 9th annual meeting of Japan Muscle Society .
• [Research] Jun/2023 Murata et al., Electrical pulse stimulation-induced tetanic exercise simulation increases the secretion of extracellular vesicles from C2C12 myotubes, Biochemical and Biophysical Research Communications, Accepted.
• [Research] Mar/2023 Nagai et al., L-Anserine increases muscle differentiation and muscle contractility in human skeletal muscle cells, Journal of Agricultural and Food Chemistry, Accepted.
• [Other] Mar/2023 Five new members! Welcome to the Honda Lab.
• [Research] Nov/20/2022 Shimizu et al., Alignment of cultured skeletal muscle cells facilitates acetylcholine receptor clustering and neuromuscular junction formation with co-cultured human iPSC-derived motor neurons, Cells, Accepted
• [Award] Oct/17/2022 Tomoya TAKASE (M2) recieved a presentation award from iACE forum in 74th SBJ Annual meeting (online).
• [Research] Aug/19/2022 Mizutani et al., Detection of protease digestion site using fluorescence labeled peptide array and construction of machine-learning prediction model, Seibutsu-kogaku Kaishi, Accepted
• [Research] Jul/7/2022 Kurotani et al., Analysis of Plasmodesmata Permeability using Cultured Tobacco BY-2 Cells Entrapped in Microfluidic Chips, Journal of Plant Research, Accepted
• [Research] Apr/27/2022 Yamamoto et al., Screening of anti-atrophic peptides by using photo-cleavable peptide array and contractile 96-well scale human skeletal muscle atrophy models, Biotechnology and Bioengineering, Accepted
• [Research] Mar/31/2022 Shimizu et al., Development of Microfluidic Chip for Entrapping Tobacco BY-2 Cells, PLOS ONE, Accepted
• [Award] Mar/25/2022 Kazuki YAMAMOTO (M2) received Best Master's Thesis Award from Meidai Kyoyu-kai.
• [Research] Nov/6/2021 Hagawa et al., Selective concentration of antimicrobial peptides to heat-treated porous silica gel using adsorption / desorption. Journal of Bioscience and Bioengineering, Accepted
• [Award] Oct/28/2021 Yuri TAKEUCHI (M1) received a presentation award from 73th SBJ Annual meeting (Online)
• [Award] Oct/27/2021 Prof. Honda received 30th Technical Award from SBJ.
• [Research] Oct/21/2021 Kinoshita et al., Agonist/antagonist activity of oxytocin variants obtained from free cyclic peptide libraries generated via amino acid substitution. ACS Omega, Accepted
• [Research] Oct/16/2021 Imai et al., In silico screening of a bile acid micelle disruption peptide for oral consumption from edible peptide database. Foods, Accepted
• [Research] Jul/20/2021 Imai et al., Machine learning screening of bile acid-binding peptides in a peptide database derived from food proteins. Scientific Reports, Accepted
• [Award] Jul/15/2021 Associate Professor Kazunori SHIMIZU received 5th Bioindustry Research Award from JBA.
• [Research] Ishihara et al.,Simple Stain-free Screening Method for Pectinolysis Microorganisms under Alkalophilic Condition. Biotechnology Letters, Accepted
• [Other] May/1/2021 Welcome new Assistant Professor, Dr. Hirokazu AKIYAMA.
• [Research] Apr/7/2021 Yamamoto, K., et al., Development of a Human Neuromuscular Tissue-on-a-Chip Model on a 24-Well-Plate-Format Compartmentalized Microfluidic Device. Lab on a Chip, Accepted
• [Research] Mar/1/2021 Yoshioka, K., et al., Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution. Biochemical and Biophysical Research Communications, Accepted
• [Research] Feb/2021 Yoshioka, K., et al., Screening of FFAR1 activating peptide by molecular structure analysis. Kagaku kogaku ronbunshu, Accepted
• [Research] Jan/2021 Yamamoto, K., et al., Compartmentalized three-dimensional human neuromuscular tissue models fabricated on a well-plate-format microdevice, has been deposited in bioRxiv as a preprint

  https://biorxiv.org/cgi/content/short/2021.01.07.424253v1

• [Research] Oct/2020 Nagashima, T., et al., In vitro model of human skeletal muscle tissues with contractility fabricated by immortalized human myogenic cells. Advanced Biosystems, Accepted
• [Research] Sep/2020 Yamashita, H., et al., Machine learning-based amino-acid substitution of short peptides: Acquisition of peptides with enhanced inhibitory activities against α-amylase and α-glucosidase. ACS Biomaterials Science & Engineering, Accepted
• [Research] Sep/2/2020 Kozaki, I., et al., Increasing the activity of cell adherent cyclic NGR peptides by optimizing the peptide length and amino acid character. Journal of Peptide Science, Accepted
• [Research] Jul/10/2020 Ito, M., et al., Bile acid micelle disruption activity of short-chain peptides from tryptic hydrolysate of edible proteins. Journal of Bioscience and Bioengineering, Accepted
• [Award] Jun/2020 Our paper [Kurimoto et al., JBB 2019] was awarded 28th Best Paper Award from The Society for Biotechnology, Japan.
• [Award] Jun/2020 Associate Professor Kazunori SHIMIZU received TERUI Award from The Society for Biotechnology, Japan.
• [Other] Mar/2020 Four new members! Welcome to the Honda Lab.
• [Seminar] Dec/4/2019 Prof. Chibuike Udenigwe (Faculty of Health Sciences, Univ. Ottawa, Canada)
• [Research] Nov/27/2019 Shimizu, K., Ohsumi, S., et al., "Fabrication of Contractile Skeletal Muscle Tissues Using Directly Converted Myoblasts from Human Fibroblasts", Journal of Bioscience and Bioengineering, Accepted
• [Research] Nov/25/2019 Kozaki, I., et al., "Disulfide linked hetero dimeric peptide arrays for screening functional peptides inside cells", Journal of Bioscience and Bioengineering, Accepted
• [Award] Associate Professor Kazunori SHIMIZU received a presentation award from CHEMINAS 40 (Actcity Hamamatsu.)
• [Award] Haruo KASSAI (M1) and Akari MURATA (M1) received a presentation award from 9th Bio-Lab Joint Seminar (Nagoya Univ.)
• [Other] Oct/2019 Lab trip to Himaka Island
• [Award] Takunori NAGASHIMA (D2) and Taiki FURUTANI (M2) received a student's presentation award from 71th SBJ's annual meeting (Okayama Univ.).
• [Award] Takunori NAGASHIMA (D2) recieved a poster award from 9th industry academia meeting (Nagoya Univ.).
• [Research] Shimizu, K., et al. "In vivo Transfection Methods Using Tissue-Suction Devices (In Japanese)" Chemical Engineering of Japan, One of the figures in this article was selected as a cover.
• [Research] Our device developed for measuring contractile force of the tissue engineered skeletal muscles was selected as a cover image of Journal of Bioscience and Bioengineering
• [Award] Associate Professor Kazunori Shimizu was awarded with the Young Scientists’ Prize in the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (MEXT)
• [Seminar] Apr/10/2019 Prof. Shinjiro Umezu (Department of Modern Mechanical Engineering, Waseda University, Japan)
• [Other] Apr/2019 Seven new members! Welcome to the Honda Lab.
• [Research] Mar/2019 Kurimoto M., et al. "Pep-MS assay: Protease hydrolysis assay system using photo-cleavable peptide array and mass spectrometer" Journal of Bioscience and Bioengineering, accepted
• [Research] 1/Jan/2019 Imai K. et al. "Predictive selection and evaluation of appropriate functional peptides for intestinal delivery with a porous silica gel" Journal of Bioscience and Bioengineering, accepted
• [Research] 27/Dec/2018 Yamaoka N. et al. "Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions" BioChip Journal, accepted
• [Award] 26/Nov/2018　Haruki Yamashita (2nd grade Master course student) received poster award from 8th Bio-Lab Joint Seminar (Nagoya Univ.)
• [Research] 25/Nov/2018 Imai K. et al. "Selective elimination of bitter peptides by adsorption to heat-treated porous silica gel" Food Science and Technology Research, accepted
• [Award] 13/Sep/2018　Saki Osumi (1st grade Master course student) received presentation award from 70th SBJ Annual meeting (Kansai Univ.)
• [Research] 5-7/Sep/2018　Prof. Hiroyuki Honda, Kento Imai, Haruki Yamashita, Saki Osumi & Masahiro Kikkawa gave presentations in "The Soviety for Biotechnology, Japan 75th Annual Meeting, Kansai Univ."
• [Research] 22-24/Aug/2018　Kento Imai & Aya Ikeda gave presentations in "The Japanese Soviety for Food Science and Technology The 65nd Annual Meeting, Tohoku Univ."
• [Research] 24/Aug/2018 Ito M. et al. "Searching for high-binding peptides to bile acid for inhibition of intestinal cholesterol absorption using principal component analysis" Journal of Bioscience and Bioengineering, accepted
• [Research] 8/Aug/2018 Nagashima T. et al. "Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine" Scientific Reports, 8, 12427 (2018)
• [Research] 5/Jul/2018 Imai K. et al. "Interaction between porous silica gel microcarriers and peptides for oral administration of functional peptides" Scientific Reports, 8, 10971 (2018)
• [Other] 6/April/2018　New members have joined.
• [Award] 14/Mar/2018　Takunori Nagashima (2nd grade Master course student) received Poster presentation award from SCEJ 83rd Annual Meeting (Kansai Univ.)
• [Research] 23/Jan/2018　Prof. Kazunori SHIMIZU gave a presentation in "The 7th Workshop of Innovative Research Center for Preventive Medical Engineering: PME, Nagoya Univ."
• [Research] 19/Jan/2018　Prof. Kazunori SHIMIZU gave a presentation in "Symposium on New Technology for Cell-based Drug Assay (Tsukuba, Japan)"
• [Award] 10/Jan/2018　Megumi Matsumoto (PhD course student) received Industrial Future Leader Award from Program for Leading Graduate Schools Forum 2017
• [Other] 27/Dec/2017　English page has launched